UBE2K protein (Gorilla gorilla) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	UBC	ENSGGOP00000023921	ENSGGOP00000001286	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.819
BRCA1	UBE2I	ENSGGOP00000023921	ENSGGOP00000034313	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.833
BRCA1	UBE2K	ENSGGOP00000023921	ENSGGOP00000003207	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.851
ENSGGOP00000047423	TRIP12	ENSGGOP00000047423	ENSGGOP00000045047	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Thyroid hormone receptor interactor 12.	0.478
ENSGGOP00000047423	UBA1	ENSGGOP00000047423	ENSGGOP00000007393	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.693
ENSGGOP00000047423	UBA52	ENSGGOP00000047423	ENSGGOP00000004534	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.894
ENSGGOP00000047423	UBA6	ENSGGOP00000047423	ENSGGOP00000014395	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin like modifier activating enzyme 6.	0.693
ENSGGOP00000047423	UBA7	ENSGGOP00000047423	ENSGGOP00000028165	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family.	0.693
ENSGGOP00000047423	UBC	ENSGGOP00000047423	ENSGGOP00000001286	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.640
ENSGGOP00000047423	UBE2I	ENSGGOP00000047423	ENSGGOP00000034313	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.708
ENSGGOP00000047423	UBE2K	ENSGGOP00000047423	ENSGGOP00000003207	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.890
NEDD4L	TRIP12	ENSGGOP00000032868	ENSGGOP00000045047	Uncharacterized protein.	Thyroid hormone receptor interactor 12.	0.442
NEDD4L	UBA1	ENSGGOP00000032868	ENSGGOP00000007393	Uncharacterized protein.	Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.442
NEDD4L	UBA52	ENSGGOP00000032868	ENSGGOP00000004534	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.608
NEDD4L	UBC	ENSGGOP00000032868	ENSGGOP00000001286	Uncharacterized protein.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.844
NEDD4L	UBE2K	ENSGGOP00000032868	ENSGGOP00000003207	Uncharacterized protein.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.862
TRIP12	ENSGGOP00000047423	ENSGGOP00000045047	ENSGGOP00000047423	Thyroid hormone receptor interactor 12.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.478
TRIP12	NEDD4L	ENSGGOP00000045047	ENSGGOP00000032868	Thyroid hormone receptor interactor 12.	Uncharacterized protein.	0.442
TRIP12	UBA1	ENSGGOP00000045047	ENSGGOP00000007393	Thyroid hormone receptor interactor 12.	Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.789
TRIP12	UBA52	ENSGGOP00000045047	ENSGGOP00000004534	Thyroid hormone receptor interactor 12.	Ubiquitin-like domain-containing protein.	0.937