Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PRUNE2Prune homolog 2 with BCH domain. (3083 aa)    
Predicted Functional Partners:
APRT
Adenine phosphoribosyltransferase.
     
 0.639
SNX2
PX domain-containing protein.
    
   0.606
FYN
Tyrosine-protein kinase.
    
   0.587
MTHFD1L
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.
      
 0.535
NAE1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
  
 0.527
APPBP2
Amyloid beta precursor protein binding protein 2.
    
 
 0.522
APBA2
Amyloid beta precursor protein binding family A member 2.
      
 0.519
TTPA
CRAL-TRIO domain-containing protein.
      
 0.489
RTN1
Reticulon.
      
 0.469
APBB2
Amyloid beta precursor protein binding family B member 2.
      
 0.453
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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