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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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[Homology]
Score
HAS3Hyaluronan synthase 3. (553 aa)    
Predicted Functional Partners:
GLA
Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family.
      
 0.697
UGDH
UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
  
 
 0.650
HMGCS2
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.635
HABP2
Hyaluronan binding protein 2.
    
 
 0.625
HYAL3
Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family.
      
 0.622
DELE1
DAP3 binding cell death enhancer 1.
  
 0.622
ILVBL
IlvB acetolactate synthase like; Belongs to the TPP enzyme family.
  
 0.615
HACL1
2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.
  
 0.615
ACAN
Aggrecan.
      
 0.607
HAS2
Hyaluronan synthase 2.
    
   0.597
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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