| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BSND | G3REL1_GORGO | ENSGGOP00000026361 | ENSGGOP00000014000 | Barttin CLCNK type accessory beta subunit. | Proprotein convertase subtilisin/kexin type 7. | 0.774 |
| BSND | LDLR | ENSGGOP00000026361 | ENSGGOP00000038549 | Barttin CLCNK type accessory beta subunit. | Low density lipoprotein receptor. | 0.713 |
| BSND | PCSK1 | ENSGGOP00000026361 | ENSGGOP00000006843 | Barttin CLCNK type accessory beta subunit. | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. | 0.785 |
| BSND | PCSK2 | ENSGGOP00000026361 | ENSGGOP00000007101 | Barttin CLCNK type accessory beta subunit. | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | 0.784 |
| BSND | PCSK9 | ENSGGOP00000026361 | ENSGGOP00000022223 | Barttin CLCNK type accessory beta subunit. | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] | 0.705 |
| BSND | USP24 | ENSGGOP00000026361 | ENSGGOP00000004251 | Barttin CLCNK type accessory beta subunit. | Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. | 0.701 |
| DDB2 | UBC | ENSGGOP00000048353 | ENSGGOP00000001286 | Damage specific DNA binding protein 2. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.583 |
| DDB2 | USP24 | ENSGGOP00000048353 | ENSGGOP00000004251 | Damage specific DNA binding protein 2. | Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. | 0.980 |
| G3REL1_GORGO | BSND | ENSGGOP00000014000 | ENSGGOP00000026361 | Proprotein convertase subtilisin/kexin type 7. | Barttin CLCNK type accessory beta subunit. | 0.774 |
| G3REL1_GORGO | LDLR | ENSGGOP00000014000 | ENSGGOP00000038549 | Proprotein convertase subtilisin/kexin type 7. | Low density lipoprotein receptor. | 0.824 |
| G3REL1_GORGO | PCSK9 | ENSGGOP00000014000 | ENSGGOP00000022223 | Proprotein convertase subtilisin/kexin type 7. | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] | 0.786 |
| G3REL1_GORGO | USP24 | ENSGGOP00000014000 | ENSGGOP00000004251 | Proprotein convertase subtilisin/kexin type 7. | Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. | 0.751 |
| LDLR | BSND | ENSGGOP00000038549 | ENSGGOP00000026361 | Low density lipoprotein receptor. | Barttin CLCNK type accessory beta subunit. | 0.713 |
| LDLR | G3REL1_GORGO | ENSGGOP00000038549 | ENSGGOP00000014000 | Low density lipoprotein receptor. | Proprotein convertase subtilisin/kexin type 7. | 0.824 |
| LDLR | PCSK1 | ENSGGOP00000038549 | ENSGGOP00000006843 | Low density lipoprotein receptor. | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. | 0.796 |
| LDLR | PCSK2 | ENSGGOP00000038549 | ENSGGOP00000007101 | Low density lipoprotein receptor. | Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. | 0.713 |
| LDLR | PCSK9 | ENSGGOP00000038549 | ENSGGOP00000022223 | Low density lipoprotein receptor. | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] | 0.998 |
| LDLR | UBC | ENSGGOP00000038549 | ENSGGOP00000001286 | Low density lipoprotein receptor. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.426 |
| LDLR | USP24 | ENSGGOP00000038549 | ENSGGOP00000004251 | Low density lipoprotein receptor. | Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. | 0.715 |
| PCSK1 | BSND | ENSGGOP00000006843 | ENSGGOP00000026361 | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. | Barttin CLCNK type accessory beta subunit. | 0.785 |
