IGF1 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	EGFR	ENSGGOP00000005698	ENSGGOP00000041101	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Receptor protein-tyrosine kinase.	0.999
EGF	G3R577_GORGO	ENSGGOP00000005698	ENSGGOP00000010446	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin like growth factor binding protein 1.	0.489
EGF	IGF1	ENSGGOP00000005698	ENSGGOP00000004843	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	IlGF domain-containing protein.	0.959
EGF	IGF1R	ENSGGOP00000005698	ENSGGOP00000012531	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase receptor.	0.951
EGF	INS	ENSGGOP00000005698	ENSGGOP00000034798	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.986
EGF	INSR	ENSGGOP00000005698	ENSGGOP00000018071	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase receptor.	0.959
EGF	TGFA	ENSGGOP00000005698	ENSGGOP00000045108	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Transforming growth factor alpha.	0.968
EGFR	EGF	ENSGGOP00000041101	ENSGGOP00000005698	Receptor protein-tyrosine kinase.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.999
EGFR	IGF1	ENSGGOP00000041101	ENSGGOP00000004843	Receptor protein-tyrosine kinase.	IlGF domain-containing protein.	0.943
EGFR	IGF1R	ENSGGOP00000041101	ENSGGOP00000012531	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.849
EGFR	IGF2	ENSGGOP00000041101	ENSGGOP00000047744	Receptor protein-tyrosine kinase.	Insulin like growth factor 2.	0.748
EGFR	INS	ENSGGOP00000041101	ENSGGOP00000034798	Receptor protein-tyrosine kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.965
EGFR	INSR	ENSGGOP00000041101	ENSGGOP00000018071	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.514
EGFR	TGFA	ENSGGOP00000041101	ENSGGOP00000045108	Receptor protein-tyrosine kinase.	Transforming growth factor alpha.	0.997
G3R577_GORGO	EGF	ENSGGOP00000010446	ENSGGOP00000005698	Insulin like growth factor binding protein 1.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.489
G3R577_GORGO	IGF1	ENSGGOP00000010446	ENSGGOP00000004843	Insulin like growth factor binding protein 1.	IlGF domain-containing protein.	0.979
G3R577_GORGO	IGF1R	ENSGGOP00000010446	ENSGGOP00000012531	Insulin like growth factor binding protein 1.	Tyrosine-protein kinase receptor.	0.555
G3R577_GORGO	IGF2	ENSGGOP00000010446	ENSGGOP00000047744	Insulin like growth factor binding protein 1.	Insulin like growth factor 2.	0.968
G3R577_GORGO	IGFBP3	ENSGGOP00000010446	ENSGGOP00000001536	Insulin like growth factor binding protein 1.	Insulin like growth factor binding protein 3.	0.463
G3R577_GORGO	IGFBP4	ENSGGOP00000010446	ENSGGOP00000009656	Insulin like growth factor binding protein 1.	Insulin like growth factor binding protein 4.	0.744