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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 0.951
FYN
Tyrosine-protein kinase.
   
 0.825
SRC
Tyrosine-protein kinase.
   
 0.720
PTPRE
Receptor-type tyrosine-protein phosphatase.
  
 
  
0.720
PTS
6-pyruvoyl tetrahydrobiopterin synthase.
    
 
 0.696
PEX11B
Peroxisomal biogenesis factor 11 beta.
      
 0.673
PTK2
Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.652
IL1RAP
Interleukin 1 receptor accessory protein.
    
 0.650
MAPK1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
 0.646
ENSGGOP00000049072
Protein kinase domain-containing protein.
   
 0.601
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.