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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAK5Non-specific serine/threonine protein kinase. (719 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42.
   
 0.985
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
    
 0.964
NCK1
Cytoplasmic protein.
    
 0.959
ARHGEF7
Rho guanine nucleotide exchange factor 7.
    
 0.957
NCK2
Cytoplasmic protein.
    
 0.953
RAC2
Rac family small GTPase 2.
   
 0.950
LIMK1
LIM domain kinase 1.
    
0.939
LIMK2
LIM domain kinase 2.
    
0.936
ROBO1
Roundabout guidance receptor 1.
   
 0.934
GNG12
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
     
  0.927
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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