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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALPIAlkaline phosphatase. (528 aa)    
Predicted Functional Partners:
ALPP
Alkaline phosphatase.
  
 
0.949
ALPL
Alkaline phosphatase.
  
  
 
0.915
NTPCR
AAA domain-containing protein.
     
  0.900
PTS
6-pyruvoyl tetrahydrobiopterin synthase.
     
  0.900
TPK1
Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.
     
  0.900
AGXT
Serine--pyruvate aminotransferase.
     
 0.718
G3QDI3_GORGO
NAD kinase.
   
 
  0.705
CHRND
Cholinergic receptor nicotinic delta subunit.
      
 0.585
INHA
Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family.
      
 0.580
TRIP11
Thyroid hormone receptor interactor 11.
   
 0.524
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.