USP43 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

USP43

Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1103 aa)

Predicted Functional Partners:

UBC

0.608

OTUB1

0.569

USP30

0.551

POLH

0.517

OTUD7A

0.509

RFC5

0.507

RFC4

0.505

REV1

0.501

RFC2

0.500

RFC3

0.498

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OTUB1	OTUD7A	ENSGGOP00000011815	ENSGGOP00000008181	OTU domain-containing protein.	OTU deubiquitinase 7A.	0.456
OTUB1	UBC	ENSGGOP00000011815	ENSGGOP00000001286	OTU domain-containing protein.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.717
OTUB1	USP30	ENSGGOP00000011815	ENSGGOP00000009391	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.432
OTUB1	USP43	ENSGGOP00000011815	ENSGGOP00000006281	OTU domain-containing protein.	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family.	0.569
OTUD7A	OTUB1	ENSGGOP00000008181	ENSGGOP00000011815	OTU deubiquitinase 7A.	OTU domain-containing protein.	0.456
OTUD7A	UBC	ENSGGOP00000008181	ENSGGOP00000001286	OTU deubiquitinase 7A.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.646
OTUD7A	USP30	ENSGGOP00000008181	ENSGGOP00000009391	OTU deubiquitinase 7A.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.466
OTUD7A	USP43	ENSGGOP00000008181	ENSGGOP00000006281	OTU deubiquitinase 7A.	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family.	0.509
POLH	REV1	ENSGGOP00000041111	ENSGGOP00000001705	UmuC domain-containing protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.963
POLH	RFC2	ENSGGOP00000041111	ENSGGOP00000042861	UmuC domain-containing protein.	Replication factor C subunit 2.	0.673
POLH	RFC3	ENSGGOP00000041111	ENSGGOP00000016778	UmuC domain-containing protein.	Replication factor C subunit 3.	0.678
POLH	RFC4	ENSGGOP00000041111	ENSGGOP00000031024	UmuC domain-containing protein.	Replication factor C subunit 4.	0.698
POLH	RFC5	ENSGGOP00000041111	ENSGGOP00000002536	UmuC domain-containing protein.	Replication factor C subunit 5.	0.668
POLH	UBC	ENSGGOP00000041111	ENSGGOP00000001286	UmuC domain-containing protein.	Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.784
POLH	USP43	ENSGGOP00000041111	ENSGGOP00000006281	UmuC domain-containing protein.	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family.	0.517
REV1	POLH	ENSGGOP00000001705	ENSGGOP00000041111	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	UmuC domain-containing protein.	0.963
REV1	RFC2	ENSGGOP00000001705	ENSGGOP00000042861	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	Replication factor C subunit 2.	0.680
REV1	RFC3	ENSGGOP00000001705	ENSGGOP00000016778	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	Replication factor C subunit 3.	0.729
REV1	RFC4	ENSGGOP00000001705	ENSGGOP00000031024	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	Replication factor C subunit 4.	0.680
REV1	RFC5	ENSGGOP00000001705	ENSGGOP00000002536	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	Replication factor C subunit 5.	0.680