| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADSL | AK3 | ENSGGOP00000014747 | ENSGGOP00000023329 | ADSL_C domain-containing protein. | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 0.969 |
| ADSL | ATIC | ENSGGOP00000014747 | ENSGGOP00000007745 | ADSL_C domain-containing protein. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.999 |
| ADSL | ENPP1 | ENSGGOP00000014747 | ENSGGOP00000010892 | ADSL_C domain-containing protein. | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | 0.900 |
| ADSL | GMPR | ENSGGOP00000014747 | ENSGGOP00000004085 | ADSL_C domain-containing protein. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.643 |
| ADSL | ITPA | ENSGGOP00000014747 | ENSGGOP00000008544 | ADSL_C domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.411 |
| ADSL | NT5C | ENSGGOP00000014747 | ENSGGOP00000004641 | ADSL_C domain-containing protein. | 5', 3'-nucleotidase, cytosolic. | 0.909 |
| ADSL | NT5C1A | ENSGGOP00000014747 | ENSGGOP00000050719 | ADSL_C domain-containing protein. | 5'-nucleotidase, cytosolic IA. | 0.928 |
| ADSL | NT5C2 | ENSGGOP00000014747 | ENSGGOP00000012935 | ADSL_C domain-containing protein. | 5'-nucleotidase, cytosolic II. | 0.908 |
| ADSL | NT5E | ENSGGOP00000014747 | ENSGGOP00000000884 | ADSL_C domain-containing protein. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.931 |
| ADSL | NT5M | ENSGGOP00000014747 | ENSGGOP00000015749 | ADSL_C domain-containing protein. | 5',3'-nucleotidase, mitochondrial. | 0.906 |
| AK3 | ADSL | ENSGGOP00000023329 | ENSGGOP00000014747 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | ADSL_C domain-containing protein. | 0.969 |
| AK3 | ENPP1 | ENSGGOP00000023329 | ENSGGOP00000010892 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Ectonucleotide pyrophosphatase/phosphodiesterase 1. | 0.924 |
| AK3 | NT5C | ENSGGOP00000023329 | ENSGGOP00000004641 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 5', 3'-nucleotidase, cytosolic. | 0.929 |
| AK3 | NT5C1A | ENSGGOP00000023329 | ENSGGOP00000050719 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 5'-nucleotidase, cytosolic IA. | 0.936 |
| AK3 | NT5C2 | ENSGGOP00000023329 | ENSGGOP00000012935 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 5'-nucleotidase, cytosolic II. | 0.900 |
| AK3 | NT5E | ENSGGOP00000023329 | ENSGGOP00000000884 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.904 |
| AK3 | NT5M | ENSGGOP00000023329 | ENSGGOP00000015749 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 5',3'-nucleotidase, mitochondrial. | 0.949 |
| ATIC | ADSL | ENSGGOP00000007745 | ENSGGOP00000014747 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | ADSL_C domain-containing protein. | 0.999 |
| ATIC | GMPR | ENSGGOP00000007745 | ENSGGOP00000004085 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.971 |
| ATIC | ITPA | ENSGGOP00000007745 | ENSGGOP00000008544 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.942 |
