| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADSS1 | ADSS2 | ENSGGOP00000012654 | ENSGGOP00000010831 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.901 |
| ADSS1 | ITPA | ENSGGOP00000012654 | ENSGGOP00000008544 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.945 |
| ADSS2 | ADSS1 | ENSGGOP00000010831 | ENSGGOP00000012654 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.901 |
| ADSS2 | ITPA | ENSGGOP00000010831 | ENSGGOP00000008544 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.945 |
| DUT | G3RK64_GORGO | ENSGGOP00000019173 | ENSGGOP00000016124 | dUTPase domain-containing protein. | Nucleoside diphosphate kinase. | 0.932 |
| DUT | ITPA | ENSGGOP00000019173 | ENSGGOP00000008544 | dUTPase domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.944 |
| DUT | NME2 | ENSGGOP00000019173 | ENSGGOP00000045691 | dUTPase domain-containing protein. | Nucleoside diphosphate kinase. | 0.932 |
| DUT | NME3 | ENSGGOP00000019173 | ENSGGOP00000006094 | dUTPase domain-containing protein. | Nucleoside diphosphate kinase. | 0.932 |
| DUT | NME4 | ENSGGOP00000019173 | ENSGGOP00000004423 | dUTPase domain-containing protein. | Nucleoside diphosphate kinase. | 0.932 |
| DUT | NME6 | ENSGGOP00000019173 | ENSGGOP00000037422 | dUTPase domain-containing protein. | Nucleoside diphosphate kinase. | 0.936 |
| DUT | NME7 | ENSGGOP00000019173 | ENSGGOP00000036712 | dUTPase domain-containing protein. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.932 |
| G3RK64_GORGO | DUT | ENSGGOP00000016124 | ENSGGOP00000019173 | Nucleoside diphosphate kinase. | dUTPase domain-containing protein. | 0.932 |
| G3RK64_GORGO | ITPA | ENSGGOP00000016124 | ENSGGOP00000008544 | Nucleoside diphosphate kinase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.952 |
| G3RK64_GORGO | NME2 | ENSGGOP00000016124 | ENSGGOP00000045691 | Nucleoside diphosphate kinase. | Nucleoside diphosphate kinase. | 0.997 |
| G3RK64_GORGO | NME3 | ENSGGOP00000016124 | ENSGGOP00000006094 | Nucleoside diphosphate kinase. | Nucleoside diphosphate kinase. | 0.998 |
| G3RK64_GORGO | NME4 | ENSGGOP00000016124 | ENSGGOP00000004423 | Nucleoside diphosphate kinase. | Nucleoside diphosphate kinase. | 0.991 |
| G3RK64_GORGO | NME6 | ENSGGOP00000016124 | ENSGGOP00000037422 | Nucleoside diphosphate kinase. | Nucleoside diphosphate kinase. | 0.920 |
| G3RK64_GORGO | NME7 | ENSGGOP00000016124 | ENSGGOP00000036712 | Nucleoside diphosphate kinase. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.912 |
| ITPA | ADSS1 | ENSGGOP00000008544 | ENSGGOP00000012654 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.945 |
| ITPA | ADSS2 | ENSGGOP00000008544 | ENSGGOP00000010831 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.945 |
