| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CWC25 | G3QXK0_GORGO | ENSGGOP00000006931 | ENSGGOP00000007545 | CWC25 spliceosome associated protein homolog. | Chromosome 1 open reading frame 109. | 0.824 |
| CWC25 | LIX1 | ENSGGOP00000006931 | ENSGGOP00000012208 | CWC25 spliceosome associated protein homolog. | Limb and CNS expressed 1. | 0.824 |
| CWC25 | MOCS3 | ENSGGOP00000006931 | ENSGGOP00000008796 | CWC25 spliceosome associated protein homolog. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.804 |
| CWC25 | SLCO1A2 | ENSGGOP00000006931 | ENSGGOP00000010457 | CWC25 spliceosome associated protein homolog. | Solute carrier organic anion transporter family member. | 0.824 |
| G3QXK0_GORGO | CWC25 | ENSGGOP00000007545 | ENSGGOP00000006931 | Chromosome 1 open reading frame 109. | CWC25 spliceosome associated protein homolog. | 0.824 |
| G3QXK0_GORGO | LIX1 | ENSGGOP00000007545 | ENSGGOP00000012208 | Chromosome 1 open reading frame 109. | Limb and CNS expressed 1. | 0.824 |
| G3QXK0_GORGO | MOCS3 | ENSGGOP00000007545 | ENSGGOP00000008796 | Chromosome 1 open reading frame 109. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.805 |
| G3QXK0_GORGO | SLCO1A2 | ENSGGOP00000007545 | ENSGGOP00000010457 | Chromosome 1 open reading frame 109. | Solute carrier organic anion transporter family member. | 0.824 |
| G3R413_GORGO | MOCS3 | ENSGGOP00000009999 | ENSGGOP00000008796 | NDUFA4 mitochondrial complex associated like 2. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.838 |
| G3R413_GORGO | MPST | ENSGGOP00000009999 | ENSGGOP00000032316 | NDUFA4 mitochondrial complex associated like 2. | Sulfurtransferase. | 0.412 |
| G3R413_GORGO | NFS1 | ENSGGOP00000009999 | ENSGGOP00000024202 | NDUFA4 mitochondrial complex associated like 2. | Aminotran_5 domain-containing protein. | 0.427 |
| G3R413_GORGO | TST | ENSGGOP00000009999 | ENSGGOP00000030289 | NDUFA4 mitochondrial complex associated like 2. | Rhodanese domain-containing protein. | 0.412 |
| G3R413_GORGO | URM1 | ENSGGOP00000009999 | ENSGGOP00000014444 | NDUFA4 mitochondrial complex associated like 2. | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for co [...] | 0.887 |
| LIX1 | CWC25 | ENSGGOP00000012208 | ENSGGOP00000006931 | Limb and CNS expressed 1. | CWC25 spliceosome associated protein homolog. | 0.824 |
| LIX1 | G3QXK0_GORGO | ENSGGOP00000012208 | ENSGGOP00000007545 | Limb and CNS expressed 1. | Chromosome 1 open reading frame 109. | 0.824 |
| LIX1 | MOCS3 | ENSGGOP00000012208 | ENSGGOP00000008796 | Limb and CNS expressed 1. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.810 |
| LIX1 | SLCO1A2 | ENSGGOP00000012208 | ENSGGOP00000010457 | Limb and CNS expressed 1. | Solute carrier organic anion transporter family member. | 0.824 |
| MOCS2 | MOCS3 | ENSGGOP00000001273 | ENSGGOP00000008796 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.992 |
| MOCS2 | MPST | ENSGGOP00000001273 | ENSGGOP00000032316 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | Sulfurtransferase. | 0.698 |
| MOCS2 | TST | ENSGGOP00000001273 | ENSGGOP00000030289 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | Rhodanese domain-containing protein. | 0.727 |
