node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADORA2A | CGA | ENSGGOP00000012399 | ENSGGOP00000030475 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | 0.809 |
ADORA2A | FSHB | ENSGGOP00000012399 | ENSGGOP00000017457 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.732 |
CGA | ADORA2A | ENSGGOP00000030475 | ENSGGOP00000012399 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | 0.809 |
CGA | FSHB | ENSGGOP00000030475 | ENSGGOP00000017457 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.999 |
CGA | FSHR | ENSGGOP00000030475 | ENSGGOP00000014079 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.996 |
CGA | LHCGR | ENSGGOP00000030475 | ENSGGOP00000008273 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.978 |
CGA | TSHR | ENSGGOP00000030475 | ENSGGOP00000018300 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.992 |
ENSGGOP00000031810 | ENSGGOP00000044584 | ENSGGOP00000031810 | ENSGGOP00000044584 | NTF2 domain-containing protein. | NTF2 domain-containing protein. | 0.552 |
ENSGGOP00000031810 | FSHB | ENSGGOP00000031810 | ENSGGOP00000017457 | NTF2 domain-containing protein. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.759 |
ENSGGOP00000031810 | NUTF2 | ENSGGOP00000031810 | ENSGGOP00000022156 | NTF2 domain-containing protein. | Nuclear transport factor 2. | 0.545 |
ENSGGOP00000044584 | ENSGGOP00000031810 | ENSGGOP00000044584 | ENSGGOP00000031810 | NTF2 domain-containing protein. | NTF2 domain-containing protein. | 0.552 |
ENSGGOP00000044584 | FSHB | ENSGGOP00000044584 | ENSGGOP00000017457 | NTF2 domain-containing protein. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.759 |
ENSGGOP00000044584 | NUTF2 | ENSGGOP00000044584 | ENSGGOP00000022156 | NTF2 domain-containing protein. | Nuclear transport factor 2. | 0.545 |
FANCA | FSHB | ENSGGOP00000010699 | ENSGGOP00000017457 | FA complementation group A. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.759 |
FSHB | ADORA2A | ENSGGOP00000017457 | ENSGGOP00000012399 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | 0.732 |
FSHB | CGA | ENSGGOP00000017457 | ENSGGOP00000030475 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | 0.999 |
FSHB | ENSGGOP00000031810 | ENSGGOP00000017457 | ENSGGOP00000031810 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | NTF2 domain-containing protein. | 0.759 |
FSHB | ENSGGOP00000044584 | ENSGGOP00000017457 | ENSGGOP00000044584 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | NTF2 domain-containing protein. | 0.759 |
FSHB | FANCA | ENSGGOP00000017457 | ENSGGOP00000010699 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | FA complementation group A. | 0.759 |
FSHB | FSHR | ENSGGOP00000017457 | ENSGGOP00000014079 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.999 |