ESR1 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000038823	ESR1	ENSGGOP00000038823	ENSGGOP00000009454	Nuclear receptor corepressor 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.996
ENSGGOP00000038823	ESR2	ENSGGOP00000038823	ENSGGOP00000002980	Nuclear receptor corepressor 1.	Estrogen receptor 2.	0.973
ENSGGOP00000038823	G3RA25_GORGO	ENSGGOP00000038823	ENSGGOP00000012280	Nuclear receptor corepressor 1.	Sp1 transcription factor.	0.606
ENSGGOP00000038823	G3S6F8_GORGO	ENSGGOP00000038823	ENSGGOP00000023665	Nuclear receptor corepressor 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.696
ENSGGOP00000038823	NCOA1	ENSGGOP00000038823	ENSGGOP00000011007	Nuclear receptor corepressor 1.	Nuclear receptor coactivator.	0.713
ENSGGOP00000038823	NCOA2	ENSGGOP00000038823	ENSGGOP00000023853	Nuclear receptor corepressor 1.	Nuclear receptor coactivator.	0.670
ENSGGOP00000038823	NCOA3	ENSGGOP00000038823	ENSGGOP00000019561	Nuclear receptor corepressor 1.	Nuclear receptor coactivator.	0.630
ENSGGOP00000038823	PGR	ENSGGOP00000038823	ENSGGOP00000024814	Nuclear receptor corepressor 1.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.859
ENSGGOP00000046735	ESR1	ENSGGOP00000046735	ENSGGOP00000009454	Non-specific serine/threonine protein kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.991
ENSGGOP00000046735	ESR2	ENSGGOP00000046735	ENSGGOP00000002980	Non-specific serine/threonine protein kinase.	Estrogen receptor 2.	0.967
ENSGGOP00000046735	PGR	ENSGGOP00000046735	ENSGGOP00000024814	Non-specific serine/threonine protein kinase.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.489
ENSGGOP00000046735	SRC	ENSGGOP00000046735	ENSGGOP00000018321	Non-specific serine/threonine protein kinase.	Tyrosine-protein kinase.	0.919
ESR1	ENSGGOP00000038823	ENSGGOP00000009454	ENSGGOP00000038823	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor corepressor 1.	0.996
ESR1	ENSGGOP00000046735	ENSGGOP00000009454	ENSGGOP00000046735	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Non-specific serine/threonine protein kinase.	0.991
ESR1	ESR2	ENSGGOP00000009454	ENSGGOP00000002980	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.999
ESR1	G3RA25_GORGO	ENSGGOP00000009454	ENSGGOP00000012280	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.997
ESR1	G3S6F8_GORGO	ENSGGOP00000009454	ENSGGOP00000023665	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.997
ESR1	NCOA1	ENSGGOP00000009454	ENSGGOP00000011007	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.997
ESR1	NCOA2	ENSGGOP00000009454	ENSGGOP00000023853	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.995
ESR1	NCOA3	ENSGGOP00000009454	ENSGGOP00000019561	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.999