| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | EP300 | ENSGGOP00000023921 | ENSGGOP00000008032 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | E1A binding protein p300. | 0.934 |
| BRCA1 | ESR1 | ENSGGOP00000023921 | ENSGGOP00000009454 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.981 |
| BRCA1 | ESR2 | ENSGGOP00000023921 | ENSGGOP00000002980 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Estrogen receptor 2. | 0.643 |
| BRCA1 | G3S4Z2_GORGO | ENSGGOP00000023921 | ENSGGOP00000023146 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Uncharacterized protein. | 0.521 |
| BRCA1 | NCOA1 | ENSGGOP00000023921 | ENSGGOP00000011007 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Nuclear receptor coactivator. | 0.441 |
| BRCA1 | NCOA2 | ENSGGOP00000023921 | ENSGGOP00000023853 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Nuclear receptor coactivator. | 0.612 |
| BRCA1 | NCOA3 | ENSGGOP00000023921 | ENSGGOP00000019561 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Nuclear receptor coactivator. | 0.492 |
| BRCA1 | SRC | ENSGGOP00000023921 | ENSGGOP00000018321 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Tyrosine-protein kinase. | 0.518 |
| EP300 | BRCA1 | ENSGGOP00000008032 | ENSGGOP00000023921 | E1A binding protein p300. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.934 |
| EP300 | ESR1 | ENSGGOP00000008032 | ENSGGOP00000009454 | E1A binding protein p300. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.978 |
| EP300 | ESR2 | ENSGGOP00000008032 | ENSGGOP00000002980 | E1A binding protein p300. | Estrogen receptor 2. | 0.836 |
| EP300 | FOS | ENSGGOP00000008032 | ENSGGOP00000000519 | E1A binding protein p300. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.899 |
| EP300 | G3S4Z2_GORGO | ENSGGOP00000008032 | ENSGGOP00000023146 | E1A binding protein p300. | Uncharacterized protein. | 0.553 |
| EP300 | NCOA1 | ENSGGOP00000008032 | ENSGGOP00000011007 | E1A binding protein p300. | Nuclear receptor coactivator. | 0.998 |
| EP300 | NCOA2 | ENSGGOP00000008032 | ENSGGOP00000023853 | E1A binding protein p300. | Nuclear receptor coactivator. | 0.996 |
| EP300 | NCOA3 | ENSGGOP00000008032 | ENSGGOP00000019561 | E1A binding protein p300. | Nuclear receptor coactivator. | 0.999 |
| EP300 | NRIP1 | ENSGGOP00000008032 | ENSGGOP00000050716 | E1A binding protein p300. | Nuclear receptor interacting protein 1. | 0.883 |
| EP300 | SRC | ENSGGOP00000008032 | ENSGGOP00000018321 | E1A binding protein p300. | Tyrosine-protein kinase. | 0.716 |
| ESR1 | BRCA1 | ENSGGOP00000009454 | ENSGGOP00000023921 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.981 |
| ESR1 | EP300 | ENSGGOP00000009454 | ENSGGOP00000008032 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | E1A binding protein p300. | 0.978 |