HMGCR protein (Gorilla gorilla) - STRING interaction network

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Score

HMGCR

3-hydroxy-3-methylglutaryl coenzyme A reductase. (911 aa)

Predicted Functional Partners:

HMGCS1

0.999

HMGCS2

0.998

MVK

0.995

G3RT31_GORGO

0.970

SQLE

0.940

PRKAG3

0.920

PRKAG2

0.920

PRKAG1

0.920

PRKAA2

0.914

PRKAA1

0.914

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3RT31_GORGO	HMGCR	ENSGGOP00000018956	ENSGGOP00000046002	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.970
G3RT31_GORGO	HMGCS1	ENSGGOP00000018956	ENSGGOP00000001124	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.705
G3RT31_GORGO	MVK	ENSGGOP00000018956	ENSGGOP00000050965	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.475
G3RT31_GORGO	SQLE	ENSGGOP00000018956	ENSGGOP00000007163	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Squalene epoxidase.	0.583
HMGCR	G3RT31_GORGO	ENSGGOP00000046002	ENSGGOP00000018956	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.970
HMGCR	HMGCS1	ENSGGOP00000046002	ENSGGOP00000001124	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
HMGCR	HMGCS2	ENSGGOP00000046002	ENSGGOP00000010047	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.998
HMGCR	MVK	ENSGGOP00000046002	ENSGGOP00000050965	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.995
HMGCR	PRKAA1	ENSGGOP00000046002	ENSGGOP00000021202	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Non-specific serine/threonine protein kinase.	0.914
HMGCR	PRKAA2	ENSGGOP00000046002	ENSGGOP00000008876	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Non-specific serine/threonine protein kinase.	0.914
HMGCR	PRKAG1	ENSGGOP00000046002	ENSGGOP00000052312	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 1.	0.920
HMGCR	PRKAG2	ENSGGOP00000046002	ENSGGOP00000014461	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.920
HMGCR	PRKAG3	ENSGGOP00000046002	ENSGGOP00000003197	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.920
HMGCR	SQLE	ENSGGOP00000046002	ENSGGOP00000007163	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Squalene epoxidase.	0.940
HMGCS1	G3RT31_GORGO	ENSGGOP00000001124	ENSGGOP00000018956	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.705
HMGCS1	HMGCR	ENSGGOP00000001124	ENSGGOP00000046002	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
HMGCS1	HMGCS2	ENSGGOP00000001124	ENSGGOP00000010047	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.915
HMGCS1	MVK	ENSGGOP00000001124	ENSGGOP00000050965	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.753
HMGCS1	SQLE	ENSGGOP00000001124	ENSGGOP00000007163	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Squalene epoxidase.	0.950
HMGCS2	HMGCR	ENSGGOP00000010047	ENSGGOP00000046002	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.998