STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)    
Predicted Functional Partners:
BECN1
Beclin 1.
    
 0.999
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
   
 0.998
PIK3R4
Phosphoinositide-3-kinase regulatory subunit 4.
   
 
 0.995
ATG14
Autophagy related 14.
     
 0.993
ULK1
Unc-51 like autophagy activating kinase 1.
   
 0.987
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.984
ULK2
Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
   
 0.977
BECN2
Beclin 2.
    
 0.976
NRBF2
Uncharacterized protein.
     
 0.966
PRKN
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 0.951
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.