PLEKHG6 protein (Gorilla gorilla) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FADD	G3QT76_GORGO	ENSGGOP00000020107	ENSGGOP00000005887	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.765
FADD	PLEKHG6	ENSGGOP00000020107	ENSGGOP00000011604	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Pleckstrin homology and RhoGEF domain containing G6.	0.677
FADD	RHOA	ENSGGOP00000020107	ENSGGOP00000012527	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Uncharacterized protein.	0.831
FADD	RIPK1	ENSGGOP00000020107	ENSGGOP00000012277	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
FADD	TRADD	ENSGGOP00000020107	ENSGGOP00000011592	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Death domain-containing protein.	0.999
G3QQ77_GORGO	G3QT76_GORGO	ENSGGOP00000004738	ENSGGOP00000005887	Neutral sphingomyelinase activation associated factor.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.788
G3QQ77_GORGO	PLEKHG6	ENSGGOP00000004738	ENSGGOP00000011604	Neutral sphingomyelinase activation associated factor.	Pleckstrin homology and RhoGEF domain containing G6.	0.636
G3QT71_GORGO	G3QT76_GORGO	ENSGGOP00000005881	ENSGGOP00000005887	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.962
G3QT71_GORGO	PLEKHG6	ENSGGOP00000005881	ENSGGOP00000011604	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	Pleckstrin homology and RhoGEF domain containing G6.	0.647
G3QT76_GORGO	FADD	ENSGGOP00000005887	ENSGGOP00000020107	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.765
G3QT76_GORGO	G3QQ77_GORGO	ENSGGOP00000005887	ENSGGOP00000004738	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Neutral sphingomyelinase activation associated factor.	0.788
G3QT76_GORGO	G3QT71_GORGO	ENSGGOP00000005887	ENSGGOP00000005881	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.962
G3QT76_GORGO	PLEKHG6	ENSGGOP00000005887	ENSGGOP00000011604	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Pleckstrin homology and RhoGEF domain containing G6.	0.746
G3QT76_GORGO	RIPK1	ENSGGOP00000005887	ENSGGOP00000012277	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Receptor interacting serine/threonine kinase 1.	0.980
G3QT76_GORGO	TRADD	ENSGGOP00000005887	ENSGGOP00000011592	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Death domain-containing protein.	0.979
PLEKHG4B	PLEKHG6	ENSGGOP00000033879	ENSGGOP00000011604	Pleckstrin homology and RhoGEF domain containing G4B.	Pleckstrin homology and RhoGEF domain containing G6.	0.682
PLEKHG6	FADD	ENSGGOP00000011604	ENSGGOP00000020107	Pleckstrin homology and RhoGEF domain containing G6.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.677
PLEKHG6	G3QQ77_GORGO	ENSGGOP00000011604	ENSGGOP00000004738	Pleckstrin homology and RhoGEF domain containing G6.	Neutral sphingomyelinase activation associated factor.	0.636
PLEKHG6	G3QT71_GORGO	ENSGGOP00000011604	ENSGGOP00000005881	Pleckstrin homology and RhoGEF domain containing G6.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.647
PLEKHG6	G3QT76_GORGO	ENSGGOP00000011604	ENSGGOP00000005887	Pleckstrin homology and RhoGEF domain containing G6.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.746