IGF1R protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB10	IGF1R	ENSGGOP00000006350	ENSGGOP00000012531	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.997
GRB10	IGF2	ENSGGOP00000006350	ENSGGOP00000047744	Growth factor receptor bound protein 10.	Insulin like growth factor 2.	0.477
GRB10	INS	ENSGGOP00000006350	ENSGGOP00000034798	Growth factor receptor bound protein 10.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.610
GRB10	INSR	ENSGGOP00000006350	ENSGGOP00000018071	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.997
GRB10	IRS1	ENSGGOP00000006350	ENSGGOP00000031038	Growth factor receptor bound protein 10.	Insulin receptor substrate 1.	0.779
GRB10	IRS2	ENSGGOP00000006350	ENSGGOP00000015108	Growth factor receptor bound protein 10.	Insulin receptor substrate 2.	0.736
GRB10	PIK3R1	ENSGGOP00000006350	ENSGGOP00000050489	Growth factor receptor bound protein 10.	Phosphoinositide-3-kinase regulatory subunit 1.	0.958
GRB10	PIK3R3	ENSGGOP00000006350	ENSGGOP00000019086	Growth factor receptor bound protein 10.	Uncharacterized protein.	0.599
GRB10	SHC1	ENSGGOP00000006350	ENSGGOP00000013082	Growth factor receptor bound protein 10.	SHC adaptor protein 1.	0.439
IGF1	IGF1R	ENSGGOP00000004843	ENSGGOP00000012531	IlGF domain-containing protein.	Tyrosine-protein kinase receptor.	0.999
IGF1	IGF2	ENSGGOP00000004843	ENSGGOP00000047744	IlGF domain-containing protein.	Insulin like growth factor 2.	0.972
IGF1	INS	ENSGGOP00000004843	ENSGGOP00000034798	IlGF domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.979
IGF1	INSR	ENSGGOP00000004843	ENSGGOP00000018071	IlGF domain-containing protein.	Tyrosine-protein kinase receptor.	0.995
IGF1	IRS1	ENSGGOP00000004843	ENSGGOP00000031038	IlGF domain-containing protein.	Insulin receptor substrate 1.	0.774
IGF1	IRS2	ENSGGOP00000004843	ENSGGOP00000015108	IlGF domain-containing protein.	Insulin receptor substrate 2.	0.738
IGF1	PIK3R1	ENSGGOP00000004843	ENSGGOP00000050489	IlGF domain-containing protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.459
IGF1	SHC1	ENSGGOP00000004843	ENSGGOP00000013082	IlGF domain-containing protein.	SHC adaptor protein 1.	0.542
IGF1R	GRB10	ENSGGOP00000012531	ENSGGOP00000006350	Tyrosine-protein kinase receptor.	Growth factor receptor bound protein 10.	0.997
IGF1R	IGF1	ENSGGOP00000012531	ENSGGOP00000004843	Tyrosine-protein kinase receptor.	IlGF domain-containing protein.	0.999
IGF1R	IGF2	ENSGGOP00000012531	ENSGGOP00000047744	Tyrosine-protein kinase receptor.	Insulin like growth factor 2.	0.997