Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HPGDSHematopoietic prostaglandin D synthase. (199 aa)    
Predicted Functional Partners:
PTGDS
Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...]
   
 
 0.964
GSTO1
Glutathione S-transferase omega 1; Belongs to the GST superfamily.
   
 0.939
GSTT2B
Uncharacterized protein; Belongs to the GST superfamily.
   
 0.935
PTGS1
Prostaglandin-endoperoxide synthase 1.
     
 0.935
G3QKD9_GORGO
Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.
   
 0.932
G3RNX6_GORGO
Thromboxane A synthase 1; Belongs to the cytochrome P450 family.
   
 
 0.930
PTGES2
Prostaglandin E synthase 2.
     
 0.927
PTGES
Prostaglandin E synthase.
   
 
 0.927
GSTO2
Glutathione S-transferase omega 2; Belongs to the GST superfamily.
   
 0.925
PTGES3
Prostaglandin E synthase 3.
   
 
 0.924
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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