STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HPGDSHematopoietic prostaglandin D synthase. (199 aa)    
Predicted Functional Partners:
PTGDS
Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...]
   
 
 0.966
PRDX6
Peroxiredoxin 6.
   
 0.961
G3RK66_GORGO
Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 
 0.950
EPHX1
Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.
   
 
 0.945
G3SB46_GORGO
Cytochrome P450 family 3 subfamily A member 4.
   
 
 0.944
GSTO1
Glutathione S-transferase omega 1; Belongs to the GST superfamily.
   
 0.943
PTGES
Prostaglandin E synthase.
     
 0.941
G3R5K4_GORGO
Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.
   
 
 0.938
ENSGGOP00000048540
Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.
   
 
 0.938
GSS
Glutathione synthetase.
   
 0.936
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.