STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TBX6T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). (436 aa)    
Predicted Functional Partners:
MESP2
Mesoderm posterior bHLH transcription factor 2.
    
 0.866
MSGN1
Mesogenin 1.
   
 0.820
G3QW78_GORGO
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
    
 0.748
TMEM70
Transmembrane protein 70.
    
 
 0.733
TMEM260
Transmembrane protein 260.
      
 0.732
ALKBH8
AlkB homolog 8, tRNA methyltransferase.
      
 0.731
ENSGGOP00000039303
Tectonic family member 1.
      
 0.731
ENSGGOP00000040711
ATR interacting protein.
      
 0.722
CPT2
Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family.
   
  
 0.718
FAM111A
Family with sequence similarity 111 member A.
      
 0.714
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.