Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)    
Predicted Functional Partners:
NES
Nestin; Belongs to the intermediate filament family.
    
 
0.921
DES
Desmin; Belongs to the intermediate filament family.
   
  0.903
VIM
Vimentin; Belongs to the intermediate filament family.
   
  0.847
AQP4
Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.823
INA
Internexin neuronal intermediate filament protein alpha; Belongs to the intermediate filament family.
   
   0.816
NEFL
Neurofilament light; Belongs to the intermediate filament family.
   
 
 0.812
CASP3
Caspase 3; Belongs to the peptidase C14A family.
   
 0.802
MAPT
Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...]
   
 
 0.780
MAPT-2
Uncharacterized protein.
   
 
 0.780
CX3CR1
C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.
      
 0.770
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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