STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FGFR1Fibroblast growth factor receptor. (820 aa)    
Predicted Functional Partners:
FGF23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
    
 0.999
KL
Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.
   
 0.999
FGF1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.999
FGF2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 0.999
FGF9
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.998
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
    
 0.998
KLB
Klotho beta.
   
 0.998
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.998
FGF4
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.997
FRS2
Fibroblast growth factor receptor substrate 2.
    
 0.997
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.