MECOM protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTBP1	CTBP2	ENSGGOP00000010279	ENSGGOP00000007148	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	C-terminal binding protein 2.	0.998
CTBP1	HDAC1	ENSGGOP00000010279	ENSGGOP00000011454	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.992
CTBP1	HDAC2	ENSGGOP00000010279	ENSGGOP00000005320	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.992
CTBP1	MECOM	ENSGGOP00000010279	ENSGGOP00000012769	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	MDS1 and EVI1 complex locus.	0.983
CTBP1	RUNX1	ENSGGOP00000010279	ENSGGOP00000034825	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.923
CTBP2	CTBP1	ENSGGOP00000007148	ENSGGOP00000010279	C-terminal binding protein 2.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.998
CTBP2	HDAC1	ENSGGOP00000007148	ENSGGOP00000011454	C-terminal binding protein 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.939
CTBP2	HDAC2	ENSGGOP00000007148	ENSGGOP00000005320	C-terminal binding protein 2.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.959
CTBP2	MECOM	ENSGGOP00000007148	ENSGGOP00000012769	C-terminal binding protein 2.	MDS1 and EVI1 complex locus.	0.953
CTBP2	RUNX1	ENSGGOP00000007148	ENSGGOP00000034825	C-terminal binding protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.913
ENSGGOP00000043319	ENSGGOP00000043767	ENSGGOP00000043319	ENSGGOP00000043767	WD_REPEATS_REGION domain-containing protein.	CAF1C_H4-bd domain-containing protein.	0.989
ENSGGOP00000043319	HDAC1	ENSGGOP00000043319	ENSGGOP00000011454	WD_REPEATS_REGION domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.997
ENSGGOP00000043319	HDAC2	ENSGGOP00000043319	ENSGGOP00000005320	WD_REPEATS_REGION domain-containing protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.997
ENSGGOP00000043319	MECOM	ENSGGOP00000043319	ENSGGOP00000012769	WD_REPEATS_REGION domain-containing protein.	MDS1 and EVI1 complex locus.	0.666
ENSGGOP00000043767	ENSGGOP00000043319	ENSGGOP00000043767	ENSGGOP00000043319	CAF1C_H4-bd domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.989
ENSGGOP00000043767	HDAC1	ENSGGOP00000043767	ENSGGOP00000011454	CAF1C_H4-bd domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.887
ENSGGOP00000043767	HDAC2	ENSGGOP00000043767	ENSGGOP00000005320	CAF1C_H4-bd domain-containing protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.884
ENSGGOP00000043767	MECOM	ENSGGOP00000043767	ENSGGOP00000012769	CAF1C_H4-bd domain-containing protein.	MDS1 and EVI1 complex locus.	0.666
HDAC1	CTBP1	ENSGGOP00000011454	ENSGGOP00000010279	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.992
HDAC1	CTBP2	ENSGGOP00000011454	ENSGGOP00000007148	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	C-terminal binding protein 2.	0.939