PPARG protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	ENSGGOP00000038823	ENSGGOP00000005899	ENSGGOP00000038823	CREB binding protein.	Nuclear receptor corepressor 1.	0.808
CREBBP	ENSGGOP00000043083	ENSGGOP00000005899	ENSGGOP00000043083	CREB binding protein.	Nuclear receptor corepressor 2.	0.772
CREBBP	EP300	ENSGGOP00000005899	ENSGGOP00000008032	CREB binding protein.	E1A binding protein p300.	0.999
CREBBP	G3S6F8_GORGO	ENSGGOP00000005899	ENSGGOP00000023665	CREB binding protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.768
CREBBP	PPARG	ENSGGOP00000005899	ENSGGOP00000032598	CREB binding protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.963
CREBBP	PPARGC1A	ENSGGOP00000005899	ENSGGOP00000009586	CREB binding protein.	PPARG coactivator 1 alpha.	0.799
CREBBP	RXRA	ENSGGOP00000005899	ENSGGOP00000041308	CREB binding protein.	Retinoid X receptor alpha.	0.901
CREBBP	RXRB	ENSGGOP00000005899	ENSGGOP00000009599	CREB binding protein.	Retinoid X receptor beta.	0.840
CREBBP	RXRG	ENSGGOP00000005899	ENSGGOP00000024205	CREB binding protein.	Retinoid X receptor gamma.	0.859
CREBBP	SIRT1	ENSGGOP00000005899	ENSGGOP00000009943	CREB binding protein.	Sirtuin 1.	0.761
ENSGGOP00000038823	CREBBP	ENSGGOP00000038823	ENSGGOP00000005899	Nuclear receptor corepressor 1.	CREB binding protein.	0.808
ENSGGOP00000038823	ENSGGOP00000043083	ENSGGOP00000038823	ENSGGOP00000043083	Nuclear receptor corepressor 1.	Nuclear receptor corepressor 2.	0.977
ENSGGOP00000038823	EP300	ENSGGOP00000038823	ENSGGOP00000008032	Nuclear receptor corepressor 1.	E1A binding protein p300.	0.861
ENSGGOP00000038823	G3S6F8_GORGO	ENSGGOP00000038823	ENSGGOP00000023665	Nuclear receptor corepressor 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.696
ENSGGOP00000038823	PPARG	ENSGGOP00000038823	ENSGGOP00000032598	Nuclear receptor corepressor 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.974
ENSGGOP00000038823	PPARGC1A	ENSGGOP00000038823	ENSGGOP00000009586	Nuclear receptor corepressor 1.	PPARG coactivator 1 alpha.	0.520
ENSGGOP00000038823	RXRA	ENSGGOP00000038823	ENSGGOP00000041308	Nuclear receptor corepressor 1.	Retinoid X receptor alpha.	0.963
ENSGGOP00000038823	RXRB	ENSGGOP00000038823	ENSGGOP00000009599	Nuclear receptor corepressor 1.	Retinoid X receptor beta.	0.905
ENSGGOP00000038823	RXRG	ENSGGOP00000038823	ENSGGOP00000024205	Nuclear receptor corepressor 1.	Retinoid X receptor gamma.	0.929
ENSGGOP00000038823	SIRT1	ENSGGOP00000038823	ENSGGOP00000009943	Nuclear receptor corepressor 1.	Sirtuin 1.	0.851