STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa)    
Predicted Functional Partners:
UBC
Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]
    
 0.724
UBA52
Ubiquitin-like domain-containing protein.
    
 0.693
ENSGGOP00000050590
Uncharacterized protein.
    
 0.672
ENSGGOP00000029233
Dishevelled segment polarity protein 1.
    
 0.669
SMAD4
Mothers against decapentaplegic homolog.
   
 0.664
NUP35
Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.
    
 
 0.660
SMAD7
MH2 domain-containing protein.
    
 0.633
G3RB41_GORGO
Mothers against decapentaplegic homolog.
    
 0.633
STK17B
Serine/threonine kinase 17b; Belongs to the protein kinase superfamily.
    
 
 0.622
G3RG63_GORGO
ISG15 ubiquitin like modifier.
    
 0.600
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.