| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BDNF | FRS2 | ENSGGOP00000032053 | ENSGGOP00000029587 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Fibroblast growth factor receptor substrate 2. | 0.869 |
| BDNF | G3QRG5_GORGO | ENSGGOP00000032053 | ENSGGOP00000005217 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Neurotrophin 4; Belongs to the NGF-beta family. | 0.959 |
| BDNF | GRB2 | ENSGGOP00000032053 | ENSGGOP00000005990 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Growth factor receptor bound protein 2. | 0.603 |
| BDNF | NGF | ENSGGOP00000032053 | ENSGGOP00000033777 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.877 |
| BDNF | NTF3 | ENSGGOP00000032053 | ENSGGOP00000043594 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.812 |
| BDNF | NTRK1 | ENSGGOP00000032053 | ENSGGOP00000040180 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Tyrosine-protein kinase receptor. | 0.977 |
| BDNF | PIK3CA | ENSGGOP00000032053 | ENSGGOP00000009158 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.795 |
| BDNF | PLCG1 | ENSGGOP00000032053 | ENSGGOP00000007654 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.657 |
| FRS2 | BDNF | ENSGGOP00000029587 | ENSGGOP00000032053 | Fibroblast growth factor receptor substrate 2. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.869 |
| FRS2 | G3QRG5_GORGO | ENSGGOP00000029587 | ENSGGOP00000005217 | Fibroblast growth factor receptor substrate 2. | Neurotrophin 4; Belongs to the NGF-beta family. | 0.797 |
| FRS2 | GRB2 | ENSGGOP00000029587 | ENSGGOP00000005990 | Fibroblast growth factor receptor substrate 2. | Growth factor receptor bound protein 2. | 0.997 |
| FRS2 | NGF | ENSGGOP00000029587 | ENSGGOP00000033777 | Fibroblast growth factor receptor substrate 2. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.610 |
| FRS2 | NTF3 | ENSGGOP00000029587 | ENSGGOP00000043594 | Fibroblast growth factor receptor substrate 2. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.424 |
| FRS2 | NTRK1 | ENSGGOP00000029587 | ENSGGOP00000040180 | Fibroblast growth factor receptor substrate 2. | Tyrosine-protein kinase receptor. | 0.987 |
| FRS2 | PIK3CA | ENSGGOP00000029587 | ENSGGOP00000009158 | Fibroblast growth factor receptor substrate 2. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.800 |
| G3QRG5_GORGO | BDNF | ENSGGOP00000005217 | ENSGGOP00000032053 | Neurotrophin 4; Belongs to the NGF-beta family. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.959 |
| G3QRG5_GORGO | FRS2 | ENSGGOP00000005217 | ENSGGOP00000029587 | Neurotrophin 4; Belongs to the NGF-beta family. | Fibroblast growth factor receptor substrate 2. | 0.797 |
| G3QRG5_GORGO | GRB2 | ENSGGOP00000005217 | ENSGGOP00000005990 | Neurotrophin 4; Belongs to the NGF-beta family. | Growth factor receptor bound protein 2. | 0.645 |
| G3QRG5_GORGO | NGF | ENSGGOP00000005217 | ENSGGOP00000033777 | Neurotrophin 4; Belongs to the NGF-beta family. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.617 |
| G3QRG5_GORGO | NTRK1 | ENSGGOP00000005217 | ENSGGOP00000040180 | Neurotrophin 4; Belongs to the NGF-beta family. | Tyrosine-protein kinase receptor. | 0.982 |
