Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACTG1Actin gamma 1. (375 aa)    
Predicted Functional Partners:
ENSGGOP00000045882
Actin beta.
  
0.999
CFL1
Cofilin 1; Belongs to the actin-binding proteins ADF family.
   
 0.998
ACTG2
Actin gamma 2, smooth muscle.
  
 
0.997
ENSGGOP00000040417
Profilin; Belongs to the profilin family.
   
 0.993
CFL2
Cofilin 2; Belongs to the actin-binding proteins ADF family.
   
 0.993
ACTBL2
Actin beta like 2.
  
 
0.992
G3S6W7_GORGO
Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.
   
 0.989
ACTR3
Actin related protein 3; Belongs to the actin family.
   
0.984
ACTL6A
Actin like 6A; Belongs to the actin family.
   
0.981
ARPC5L
Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
   
 0.980
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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