node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLEC4M | ENSGGOP00000042710 | ENSGGOP00000021876 | ENSGGOP00000042710 | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). | Integrin beta. | 0.413 |
CLEC4M | ICAM1 | ENSGGOP00000021876 | ENSGGOP00000038077 | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. | 0.591 |
CLEC4M | ICAM2 | ENSGGOP00000021876 | ENSGGOP00000013761 | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). | Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). | 0.961 |
CLEC4M | ICAM3 | ENSGGOP00000021876 | ENSGGOP00000005895 | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). | Ig-like domain-containing protein. | 0.963 |
CLEC4M | ITGAM | ENSGGOP00000021876 | ENSGGOP00000004003 | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). | Integrin subunit alpha M; Belongs to the integrin alpha chain family. | 0.677 |
CLEC6A | ICAM2 | ENSGGOP00000024618 | ENSGGOP00000013761 | C-type lectin domain containing 6A. | Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). | 0.752 |
CLEC6A | ICAM3 | ENSGGOP00000024618 | ENSGGOP00000005895 | C-type lectin domain containing 6A. | Ig-like domain-containing protein. | 0.519 |
ENSGGOP00000042710 | CLEC4M | ENSGGOP00000042710 | ENSGGOP00000021876 | Integrin beta. | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). | 0.413 |
ENSGGOP00000042710 | F11R | ENSGGOP00000042710 | ENSGGOP00000000083 | Integrin beta. | F11 receptor. | 0.854 |
ENSGGOP00000042710 | ICAM1 | ENSGGOP00000042710 | ENSGGOP00000038077 | Integrin beta. | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. | 0.991 |
ENSGGOP00000042710 | ICAM2 | ENSGGOP00000042710 | ENSGGOP00000013761 | Integrin beta. | Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). | 0.895 |
ENSGGOP00000042710 | ICAM3 | ENSGGOP00000042710 | ENSGGOP00000005895 | Integrin beta. | Ig-like domain-containing protein. | 0.890 |
ENSGGOP00000042710 | ITGAL | ENSGGOP00000042710 | ENSGGOP00000049292 | Integrin beta. | Integrin subunit alpha L; Belongs to the integrin alpha chain family. | 0.999 |
ENSGGOP00000042710 | ITGAM | ENSGGOP00000042710 | ENSGGOP00000004003 | Integrin beta. | Integrin subunit alpha M; Belongs to the integrin alpha chain family. | 0.999 |
EZR | ICAM1 | ENSGGOP00000038542 | ENSGGOP00000038077 | Ezrin. | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. | 0.979 |
EZR | ICAM2 | ENSGGOP00000038542 | ENSGGOP00000013761 | Ezrin. | Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). | 0.813 |
EZR | RDX | ENSGGOP00000038542 | ENSGGOP00000021643 | Ezrin. | Radixin. | 0.999 |
F11R | ENSGGOP00000042710 | ENSGGOP00000000083 | ENSGGOP00000042710 | F11 receptor. | Integrin beta. | 0.854 |
F11R | ICAM1 | ENSGGOP00000000083 | ENSGGOP00000038077 | F11 receptor. | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. | 0.653 |
F11R | ICAM2 | ENSGGOP00000000083 | ENSGGOP00000013761 | F11 receptor. | Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). | 0.735 |