| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSGGOP00000037033 | ENSGGOP00000047060 | ENSGGOP00000037033 | ENSGGOP00000047060 | Uncharacterized protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.584 |
| ENSGGOP00000037033 | RNF8 | ENSGGOP00000037033 | ENSGGOP00000014628 | Uncharacterized protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.905 |
| ENSGGOP00000037033 | TP53BP1 | ENSGGOP00000037033 | ENSGGOP00000002557 | Uncharacterized protein. | Tumor protein p53 binding protein 1. | 0.438 |
| ENSGGOP00000037033 | UBC | ENSGGOP00000037033 | ENSGGOP00000001286 | Uncharacterized protein. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.558 |
| ENSGGOP00000037033 | UBE2N | ENSGGOP00000037033 | ENSGGOP00000033905 | Uncharacterized protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.659 |
| ENSGGOP00000047060 | ENSGGOP00000037033 | ENSGGOP00000047060 | ENSGGOP00000037033 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Uncharacterized protein. | 0.584 |
| ENSGGOP00000047060 | G3QYE9_GORGO | ENSGGOP00000047060 | ENSGGOP00000007882 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Histone H2A; Belongs to the histone H2A family. | 0.450 |
| ENSGGOP00000047060 | HERC2 | ENSGGOP00000047060 | ENSGGOP00000017742 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | 0.584 |
| ENSGGOP00000047060 | MDC1 | ENSGGOP00000047060 | ENSGGOP00000000718 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Mediator of DNA damage checkpoint 1. | 0.620 |
| ENSGGOP00000047060 | RNF8 | ENSGGOP00000047060 | ENSGGOP00000014628 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.925 |
| ENSGGOP00000047060 | TP53BP1 | ENSGGOP00000047060 | ENSGGOP00000002557 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Tumor protein p53 binding protein 1. | 0.693 |
| ENSGGOP00000047060 | UBC | ENSGGOP00000047060 | ENSGGOP00000001286 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.864 |
| ENSGGOP00000047060 | UBE2D3 | ENSGGOP00000047060 | ENSGGOP00000001352 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. | 0.474 |
| ENSGGOP00000047060 | UBE2E2 | ENSGGOP00000047060 | ENSGGOP00000047260 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. | 0.444 |
| G3QYE9_GORGO | ENSGGOP00000047060 | ENSGGOP00000007882 | ENSGGOP00000047060 | Histone H2A; Belongs to the histone H2A family. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.450 |
| G3QYE9_GORGO | MDC1 | ENSGGOP00000007882 | ENSGGOP00000000718 | Histone H2A; Belongs to the histone H2A family. | Mediator of DNA damage checkpoint 1. | 0.974 |
| G3QYE9_GORGO | RNF8 | ENSGGOP00000007882 | ENSGGOP00000014628 | Histone H2A; Belongs to the histone H2A family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.928 |
| G3QYE9_GORGO | TP53BP1 | ENSGGOP00000007882 | ENSGGOP00000002557 | Histone H2A; Belongs to the histone H2A family. | Tumor protein p53 binding protein 1. | 0.979 |
| G3QYE9_GORGO | UBC | ENSGGOP00000007882 | ENSGGOP00000001286 | Histone H2A; Belongs to the histone H2A family. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.491 |
| G3QYE9_GORGO | UBE2N | ENSGGOP00000007882 | ENSGGOP00000033905 | Histone H2A; Belongs to the histone H2A family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.536 |
