| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHCY | CTH | ENSGGOP00000027625 | ENSGGOP00000016141 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Cystathionine gamma-lyase. | 0.936 |
| AHCY | MAT1A | ENSGGOP00000027625 | ENSGGOP00000005739 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.699 |
| AHCY | MAT2A | ENSGGOP00000027625 | ENSGGOP00000004838 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.655 |
| AHCY | MTHFR | ENSGGOP00000027625 | ENSGGOP00000030609 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.549 |
| AHCY | MTR | ENSGGOP00000027625 | ENSGGOP00000015745 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.968 |
| AHCY | SHMT1 | ENSGGOP00000027625 | ENSGGOP00000030416 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.569 |
| CTH | AHCY | ENSGGOP00000016141 | ENSGGOP00000027625 | Cystathionine gamma-lyase. | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | 0.936 |
| CTH | MAT1A | ENSGGOP00000016141 | ENSGGOP00000005739 | Cystathionine gamma-lyase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.467 |
| CTH | MAT2A | ENSGGOP00000016141 | ENSGGOP00000004838 | Cystathionine gamma-lyase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.467 |
| CTH | MTHFR | ENSGGOP00000016141 | ENSGGOP00000030609 | Cystathionine gamma-lyase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.949 |
| CTH | MTR | ENSGGOP00000016141 | ENSGGOP00000015745 | Cystathionine gamma-lyase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.983 |
| CTH | MTRR | ENSGGOP00000016141 | ENSGGOP00000046668 | Cystathionine gamma-lyase. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.710 |
| DMGDH | MTHFD1 | ENSGGOP00000003151 | ENSGGOP00000018507 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. | 0.927 |
| DMGDH | MTHFD1L | ENSGGOP00000003151 | ENSGGOP00000003590 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.939 |
| DMGDH | MTHFR | ENSGGOP00000003151 | ENSGGOP00000030609 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.978 |
| DMGDH | MTR | ENSGGOP00000003151 | ENSGGOP00000015745 | Dimethylglycine dehydrogenase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.968 |
| DMGDH | SHMT1 | ENSGGOP00000003151 | ENSGGOP00000030416 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.976 |
| MAT1A | AHCY | ENSGGOP00000005739 | ENSGGOP00000027625 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | 0.699 |
| MAT1A | CTH | ENSGGOP00000005739 | ENSGGOP00000016141 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Cystathionine gamma-lyase. | 0.467 |
| MAT1A | MAT2A | ENSGGOP00000005739 | ENSGGOP00000004838 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.991 |
