| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| G3QDX1_GORGO | TPMT | ENSGGOP00000000452 | ENSGGOP00000015758 | Uncharacterized protein. | Thiopurine S-methyltransferase. | 0.679 |
| G3R7U8_GORGO | GGH | ENSGGOP00000011445 | ENSGGOP00000007573 | Solute carrier family 19 member 1. | Folate gamma-glutamyl hydrolase. | 0.740 |
| G3R7U8_GORGO | TPMT | ENSGGOP00000011445 | ENSGGOP00000015758 | Solute carrier family 19 member 1. | Thiopurine S-methyltransferase. | 0.703 |
| G3RX57_GORGO | TPMT | ENSGGOP00000020392 | ENSGGOP00000015758 | Uncharacterized protein. | Thiopurine S-methyltransferase. | 0.650 |
| GGH | G3R7U8_GORGO | ENSGGOP00000007573 | ENSGGOP00000011445 | Folate gamma-glutamyl hydrolase. | Solute carrier family 19 member 1. | 0.740 |
| GGH | TPMT | ENSGGOP00000007573 | ENSGGOP00000015758 | Folate gamma-glutamyl hydrolase. | Thiopurine S-methyltransferase. | 0.699 |
| GMPS | HPRT1 | ENSGGOP00000016670 | ENSGGOP00000027942 | Guanine monophosphate synthase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.929 |
| GMPS | IMPDH | ENSGGOP00000016670 | ENSGGOP00000012922 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.986 |
| GMPS | IMPDH-2 | ENSGGOP00000016670 | ENSGGOP00000041950 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.989 |
| GMPS | ITPA | ENSGGOP00000016670 | ENSGGOP00000008544 | Guanine monophosphate synthase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.939 |
| GMPS | TPMT | ENSGGOP00000016670 | ENSGGOP00000015758 | Guanine monophosphate synthase. | Thiopurine S-methyltransferase. | 0.922 |
| HPRT1 | GMPS | ENSGGOP00000027942 | ENSGGOP00000016670 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanine monophosphate synthase. | 0.929 |
| HPRT1 | IMPDH | ENSGGOP00000027942 | ENSGGOP00000012922 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.936 |
| HPRT1 | IMPDH-2 | ENSGGOP00000027942 | ENSGGOP00000041950 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.922 |
| HPRT1 | ITPA | ENSGGOP00000027942 | ENSGGOP00000008544 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.922 |
| HPRT1 | TPMT | ENSGGOP00000027942 | ENSGGOP00000015758 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Thiopurine S-methyltransferase. | 0.946 |
| HPRT1 | XDH | ENSGGOP00000027942 | ENSGGOP00000011154 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine dehydrogenase. | 0.921 |
| IMPDH | GMPS | ENSGGOP00000012922 | ENSGGOP00000016670 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | Guanine monophosphate synthase. | 0.986 |
| IMPDH | HPRT1 | ENSGGOP00000012922 | ENSGGOP00000027942 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.936 |
| IMPDH | IMPDH-2 | ENSGGOP00000012922 | ENSGGOP00000041950 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.988 |
