STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINA4Serpin family A member 4; Belongs to the serpin family. (427 aa)    
Predicted Functional Partners:
KLK1
Kallikrein 1; Belongs to the peptidase S1 family.
    
 0.922
KLK4
Kallikrein related peptidase 4; Belongs to the peptidase S1 family.
    
 0.696
PI3
Peptidase inhibitor 3.
      
 0.672
SERPIND1
Serpin family D member 1; Belongs to the serpin family.
  
 
0.628
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 
 0.586
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
   
 0.586
G3QF49_GORGO
Azurocidin 1.
    
 0.567
ENSGGOP00000041777
SERPIN domain-containing protein; Belongs to the serpin family.
  
 0.566
G3S9Q7_GORGO
Uncharacterized protein; Belongs to the serpin family.
  
0.550
OSBP
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.506
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.