| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B1 | QDPR | ENSGGOP00000011443 | ENSGGOP00000004032 | Aldo-keto reductase family 1 member B. | Quinoid dihydropteridine reductase. | 0.919 |
| AKR1B1 | SPR | ENSGGOP00000011443 | ENSGGOP00000005562 | Aldo-keto reductase family 1 member B. | Sepiapterin reductase. | 0.947 |
| AKR1B1 | TPH1 | ENSGGOP00000011443 | ENSGGOP00000016927 | Aldo-keto reductase family 1 member B. | Tryptophan hydroxylase 1. | 0.913 |
| AKR1B1 | TPH2 | ENSGGOP00000011443 | ENSGGOP00000012644 | Aldo-keto reductase family 1 member B. | Tryptophan hydroxylase 2. | 0.902 |
| DDC | IDO1 | ENSGGOP00000045069 | ENSGGOP00000028211 | Dopa decarboxylase. | Indoleamine 2,3-dioxygenase 1. | 0.957 |
| DDC | IDO2 | ENSGGOP00000045069 | ENSGGOP00000037362 | Dopa decarboxylase. | Indoleamine 2,3-dioxygenase 2. | 0.946 |
| DDC | QDPR | ENSGGOP00000045069 | ENSGGOP00000004032 | Dopa decarboxylase. | Quinoid dihydropteridine reductase. | 0.435 |
| DDC | TDO2 | ENSGGOP00000045069 | ENSGGOP00000020021 | Dopa decarboxylase. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.952 |
| DDC | TPH1 | ENSGGOP00000045069 | ENSGGOP00000016927 | Dopa decarboxylase. | Tryptophan hydroxylase 1. | 0.970 |
| DDC | TPH2 | ENSGGOP00000045069 | ENSGGOP00000012644 | Dopa decarboxylase. | Tryptophan hydroxylase 2. | 0.959 |
| IDO1 | DDC | ENSGGOP00000028211 | ENSGGOP00000045069 | Indoleamine 2,3-dioxygenase 1. | Dopa decarboxylase. | 0.957 |
| IDO1 | IDO2 | ENSGGOP00000028211 | ENSGGOP00000037362 | Indoleamine 2,3-dioxygenase 1. | Indoleamine 2,3-dioxygenase 2. | 0.928 |
| IDO1 | TDO2 | ENSGGOP00000028211 | ENSGGOP00000020021 | Indoleamine 2,3-dioxygenase 1. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.973 |
| IDO1 | TPH1 | ENSGGOP00000028211 | ENSGGOP00000016927 | Indoleamine 2,3-dioxygenase 1. | Tryptophan hydroxylase 1. | 0.948 |
| IDO1 | TPH2 | ENSGGOP00000028211 | ENSGGOP00000012644 | Indoleamine 2,3-dioxygenase 1. | Tryptophan hydroxylase 2. | 0.962 |
| IDO2 | DDC | ENSGGOP00000037362 | ENSGGOP00000045069 | Indoleamine 2,3-dioxygenase 2. | Dopa decarboxylase. | 0.946 |
| IDO2 | IDO1 | ENSGGOP00000037362 | ENSGGOP00000028211 | Indoleamine 2,3-dioxygenase 2. | Indoleamine 2,3-dioxygenase 1. | 0.928 |
| IDO2 | TDO2 | ENSGGOP00000037362 | ENSGGOP00000020021 | Indoleamine 2,3-dioxygenase 2. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.980 |
| IDO2 | TPH1 | ENSGGOP00000037362 | ENSGGOP00000016927 | Indoleamine 2,3-dioxygenase 2. | Tryptophan hydroxylase 1. | 0.957 |
| IDO2 | TPH2 | ENSGGOP00000037362 | ENSGGOP00000012644 | Indoleamine 2,3-dioxygenase 2. | Tryptophan hydroxylase 2. | 0.974 |
