| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOE | APP | ENSGGOP00000006232 | ENSGGOP00000049928 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Amyloid beta precursor protein. | 0.980 |
| APOE | CASP3 | ENSGGOP00000006232 | ENSGGOP00000021659 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Caspase 3; Belongs to the peptidase C14A family. | 0.569 |
| APOE | G3RIZ8_GORGO | ENSGGOP00000006232 | ENSGGOP00000015667 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Bridging integrator 1. | 0.641 |
| APOE | MAPT | ENSGGOP00000006232 | ENSGGOP00000005406 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] | 0.865 |
| APOE | SNCA | ENSGGOP00000006232 | ENSGGOP00000027281 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.935 |
| APP | APOE | ENSGGOP00000049928 | ENSGGOP00000006232 | Amyloid beta precursor protein. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.980 |
| APP | CASP3 | ENSGGOP00000049928 | ENSGGOP00000021659 | Amyloid beta precursor protein. | Caspase 3; Belongs to the peptidase C14A family. | 0.828 |
| APP | ENSGGOP00000043662 | ENSGGOP00000049928 | ENSGGOP00000043662 | Amyloid beta precursor protein. | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. | 0.664 |
| APP | GSK3B | ENSGGOP00000049928 | ENSGGOP00000007214 | Amyloid beta precursor protein. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.832 |
| APP | MAPT | ENSGGOP00000049928 | ENSGGOP00000005406 | Amyloid beta precursor protein. | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] | 0.909 |
| APP | SNCA | ENSGGOP00000049928 | ENSGGOP00000027281 | Amyloid beta precursor protein. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.948 |
| APP | YWHAQ | ENSGGOP00000049928 | ENSGGOP00000001546 | Amyloid beta precursor protein. | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. | 0.609 |
| CASP3 | APOE | ENSGGOP00000021659 | ENSGGOP00000006232 | Caspase 3; Belongs to the peptidase C14A family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.569 |
| CASP3 | APP | ENSGGOP00000021659 | ENSGGOP00000049928 | Caspase 3; Belongs to the peptidase C14A family. | Amyloid beta precursor protein. | 0.828 |
| CASP3 | ENSGGOP00000043662 | ENSGGOP00000021659 | ENSGGOP00000043662 | Caspase 3; Belongs to the peptidase C14A family. | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. | 0.537 |
| CASP3 | GSK3B | ENSGGOP00000021659 | ENSGGOP00000007214 | Caspase 3; Belongs to the peptidase C14A family. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.530 |
| CASP3 | MAPT | ENSGGOP00000021659 | ENSGGOP00000005406 | Caspase 3; Belongs to the peptidase C14A family. | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] | 0.859 |
| CASP3 | SNCA | ENSGGOP00000021659 | ENSGGOP00000027281 | Caspase 3; Belongs to the peptidase C14A family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.601 |
| ENSGGOP00000043662 | APP | ENSGGOP00000043662 | ENSGGOP00000049928 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. | Amyloid beta precursor protein. | 0.664 |
| ENSGGOP00000043662 | CASP3 | ENSGGOP00000043662 | ENSGGOP00000021659 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. | Caspase 3; Belongs to the peptidase C14A family. | 0.537 |
