| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FSHB | GNB1 | ENSGGOP00000017457 | ENSGGOP00000035487 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | G protein subunit beta 1. | 0.611 |
| FSHB | GNB4 | ENSGGOP00000017457 | ENSGGOP00000025314 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | G protein subunit beta 4. | 0.429 |
| FSHB | GNG2 | ENSGGOP00000017457 | ENSGGOP00000029199 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | G protein gamma domain-containing protein. | 0.613 |
| FSHB | GNG4 | ENSGGOP00000017457 | ENSGGOP00000007723 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.428 |
| FSHB | TSHB | ENSGGOP00000017457 | ENSGGOP00000010131 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Thyroid stimulating hormone subunit beta. | 0.452 |
| FSHB | TSHR | ENSGGOP00000017457 | ENSGGOP00000018300 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.990 |
| GNAS | GNB1 | ENSGGOP00000002801 | ENSGGOP00000035487 | GNAS complex locus. | G protein subunit beta 1. | 0.996 |
| GNAS | GNB2 | ENSGGOP00000002801 | ENSGGOP00000040379 | GNAS complex locus. | G protein subunit beta 2. | 0.989 |
| GNAS | GNB4 | ENSGGOP00000002801 | ENSGGOP00000025314 | GNAS complex locus. | G protein subunit beta 4. | 0.989 |
| GNAS | GNG2 | ENSGGOP00000002801 | ENSGGOP00000029199 | GNAS complex locus. | G protein gamma domain-containing protein. | 0.985 |
| GNAS | GNG4 | ENSGGOP00000002801 | ENSGGOP00000007723 | GNAS complex locus. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.994 |
| GNAS | TSHR | ENSGGOP00000002801 | ENSGGOP00000018300 | GNAS complex locus. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.978 |
| GNB1 | FSHB | ENSGGOP00000035487 | ENSGGOP00000017457 | G protein subunit beta 1. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. | 0.611 |
| GNB1 | GNAS | ENSGGOP00000035487 | ENSGGOP00000002801 | G protein subunit beta 1. | GNAS complex locus. | 0.996 |
| GNB1 | GNB2 | ENSGGOP00000035487 | ENSGGOP00000040379 | G protein subunit beta 1. | G protein subunit beta 2. | 0.999 |
| GNB1 | GNB4 | ENSGGOP00000035487 | ENSGGOP00000025314 | G protein subunit beta 1. | G protein subunit beta 4. | 0.997 |
| GNB1 | GNG2 | ENSGGOP00000035487 | ENSGGOP00000029199 | G protein subunit beta 1. | G protein gamma domain-containing protein. | 0.982 |
| GNB1 | GNG4 | ENSGGOP00000035487 | ENSGGOP00000007723 | G protein subunit beta 1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.996 |
| GNB1 | TSHB | ENSGGOP00000035487 | ENSGGOP00000010131 | G protein subunit beta 1. | Thyroid stimulating hormone subunit beta. | 0.676 |
| GNB1 | TSHR | ENSGGOP00000035487 | ENSGGOP00000018300 | G protein subunit beta 1. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.931 |
