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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)    
Predicted Functional Partners:
LMNB1
Lamin B1; Belongs to the intermediate filament family.
   
 0.969
LMNA
Lamin A/C; Belongs to the intermediate filament family.
   
 0.968
CASP9
Caspase 9; Belongs to the peptidase C14A family.
    
0.966
ENSGGOP00000033404
Caspase 8; Belongs to the peptidase C14A family.
   
0.931
ENSGGOP00000045882
Actin beta.
    
 0.928
ACTG1
Actin gamma 1.
    
 0.910
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 
0.841
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.810
APP
Amyloid beta precursor protein.
   
 
 0.742
RIPK3
Receptor interacting serine/threonine kinase 3.
   
 0.725
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.