PIK3R3 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PIK3R3

Uncharacterized protein. (507 aa)

Predicted Functional Partners:

PIK3CA

0.999

PIK3CB

0.999

PIK3R1

0.999

G3R9L0_GORGO

0.997

EGFR

0.995

IGF1R

0.987

PTK2

0.987

IRS1

0.987

IRS4

0.984

GAB1

0.982

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	G3R9L0_GORGO	ENSGGOP00000041101	ENSGGOP00000012094	Receptor protein-tyrosine kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	0.981
EGFR	GAB1	ENSGGOP00000041101	ENSGGOP00000000019	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.997
EGFR	IGF1R	ENSGGOP00000041101	ENSGGOP00000012531	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.849
EGFR	IRS1	ENSGGOP00000041101	ENSGGOP00000031038	Receptor protein-tyrosine kinase.	Insulin receptor substrate 1.	0.809
EGFR	PIK3CA	ENSGGOP00000041101	ENSGGOP00000009158	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.997
EGFR	PIK3CB	ENSGGOP00000041101	ENSGGOP00000009368	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.994
EGFR	PIK3R1	ENSGGOP00000041101	ENSGGOP00000050489	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.997
EGFR	PIK3R3	ENSGGOP00000041101	ENSGGOP00000019086	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.995
EGFR	PTK2	ENSGGOP00000041101	ENSGGOP00000021868	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.994
G3R9L0_GORGO	EGFR	ENSGGOP00000012094	ENSGGOP00000041101	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Receptor protein-tyrosine kinase.	0.981
G3R9L0_GORGO	GAB1	ENSGGOP00000012094	ENSGGOP00000000019	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	GRB2 associated binding protein 1.	0.967
G3R9L0_GORGO	IGF1R	ENSGGOP00000012094	ENSGGOP00000012531	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein kinase receptor.	0.967
G3R9L0_GORGO	IRS1	ENSGGOP00000012094	ENSGGOP00000031038	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Insulin receptor substrate 1.	0.981
G3R9L0_GORGO	IRS4	ENSGGOP00000012094	ENSGGOP00000040896	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Insulin receptor substrate 4.	0.966
G3R9L0_GORGO	PIK3CA	ENSGGOP00000012094	ENSGGOP00000009158	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.985
G3R9L0_GORGO	PIK3CB	ENSGGOP00000012094	ENSGGOP00000009368	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.973
G3R9L0_GORGO	PIK3R1	ENSGGOP00000012094	ENSGGOP00000050489	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Phosphoinositide-3-kinase regulatory subunit 1.	0.999
G3R9L0_GORGO	PIK3R3	ENSGGOP00000012094	ENSGGOP00000019086	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.997
G3R9L0_GORGO	PTK2	ENSGGOP00000012094	ENSGGOP00000021868	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.973
GAB1	EGFR	ENSGGOP00000000019	ENSGGOP00000041101	GRB2 associated binding protein 1.	Receptor protein-tyrosine kinase.	0.997