STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
G3RV54_GORGOProtein tyrosine phosphatase receptor type C. (1306 aa)    
Predicted Functional Partners:
LCK
Tyrosine-protein kinase.
   
 0.981
SEMA4D
Semaphorin 4D; Belongs to the semaphorin family.
    
 0.943
LCP2
Lymphocyte cytosolic protein 2.
   
 
 0.901
CD22
B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]
   
 0.889
SPN
Sialophorin.
   
 
 0.879
PTPRCAP
Protein tyrosine phosphatase receptor type C associated protein.
   
 
 0.850
DPP4
Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.
   
 
 0.823
ITGAL
Integrin subunit alpha L; Belongs to the integrin alpha chain family.
   
 0.822
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.803
CD53
Tetraspanin.
   
 0.802
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.