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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)    
Predicted Functional Partners:
BECN1
Beclin 1.
    
 0.999
UVRAG
UV radiation resistance associated.
    
 0.999
NRBF2
Uncharacterized protein.
    
 0.999
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
   
 0.999
ATG14
Autophagy related 14.
    
 0.999
BECN2
Beclin 2.
    
 0.996
AMBRA1
Autophagy and beclin 1 regulator 1.
   
 
 0.995
ULK1
Unc-51 like autophagy activating kinase 1.
    
 0.993
ULK2
Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
    
 0.992
RB1CC1
RB1 inducible coiled-coil 1.
     
 0.983
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.