TRAF6 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	G3QHL6_GORGO	ENSGGOP00000008804	ENSGGOP00000001846	IKKbetaNEMObind domain-containing protein.	Interleukin 1 receptor associated kinase 2.	0.648
CHUK	IKBKB	ENSGGOP00000008804	ENSGGOP00000006628	IKKbetaNEMObind domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	IRAK1	ENSGGOP00000008804	ENSGGOP00000018313	IKKbetaNEMObind domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.983
CHUK	MAP3K7	ENSGGOP00000008804	ENSGGOP00000020634	IKKbetaNEMObind domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.997
CHUK	MYD88	ENSGGOP00000008804	ENSGGOP00000003761	IKKbetaNEMObind domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.552
CHUK	TAB1	ENSGGOP00000008804	ENSGGOP00000007837	IKKbetaNEMObind domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.976
CHUK	TAB2	ENSGGOP00000008804	ENSGGOP00000016323	IKKbetaNEMObind domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.979
CHUK	TAB3	ENSGGOP00000008804	ENSGGOP00000019053	IKKbetaNEMObind domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.978
CHUK	TNFAIP3	ENSGGOP00000008804	ENSGGOP00000003280	IKKbetaNEMObind domain-containing protein.	TNF alpha induced protein 3.	0.773
CHUK	TRAF6	ENSGGOP00000008804	ENSGGOP00000005734	IKKbetaNEMObind domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.998
G3QHL6_GORGO	CHUK	ENSGGOP00000001846	ENSGGOP00000008804	Interleukin 1 receptor associated kinase 2.	IKKbetaNEMObind domain-containing protein.	0.648
G3QHL6_GORGO	IKBKB	ENSGGOP00000001846	ENSGGOP00000006628	Interleukin 1 receptor associated kinase 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.639
G3QHL6_GORGO	IRAK1	ENSGGOP00000001846	ENSGGOP00000018313	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 1.	0.990
G3QHL6_GORGO	MAP3K7	ENSGGOP00000001846	ENSGGOP00000020634	Interleukin 1 receptor associated kinase 2.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.862
G3QHL6_GORGO	MYD88	ENSGGOP00000001846	ENSGGOP00000003761	Interleukin 1 receptor associated kinase 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.993
G3QHL6_GORGO	TAB1	ENSGGOP00000001846	ENSGGOP00000007837	Interleukin 1 receptor associated kinase 2.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.737
G3QHL6_GORGO	TAB2	ENSGGOP00000001846	ENSGGOP00000016323	Interleukin 1 receptor associated kinase 2.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.902
G3QHL6_GORGO	TAB3	ENSGGOP00000001846	ENSGGOP00000019053	Interleukin 1 receptor associated kinase 2.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.840
G3QHL6_GORGO	TRAF6	ENSGGOP00000001846	ENSGGOP00000005734	Interleukin 1 receptor associated kinase 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IKBKB	CHUK	ENSGGOP00000006628	ENSGGOP00000008804	Inhibitor of nuclear factor kappa B kinase subunit beta.	IKKbetaNEMObind domain-containing protein.	0.999