PTK2 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PTK2

Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)

Predicted Functional Partners:

GRB2

0.999

SRC

0.999

EGFR

0.999

BCAR1

0.999

SOS1

0.998

ENSGGOP00000044113

0.995

FYN

0.993

DCC

0.990

PTEN

0.989

ITGB1

0.987

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	EGFR	ENSGGOP00000052326	ENSGGOP00000041101	BCAR1 scaffold protein, Cas family member.	Receptor protein-tyrosine kinase.	0.571
BCAR1	ENSGGOP00000044113	ENSGGOP00000052326	ENSGGOP00000044113	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein.	0.978
BCAR1	FYN	ENSGGOP00000052326	ENSGGOP00000007888	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.949
BCAR1	GRB2	ENSGGOP00000052326	ENSGGOP00000005990	BCAR1 scaffold protein, Cas family member.	Growth factor receptor bound protein 2.	0.878
BCAR1	ITGB1	ENSGGOP00000052326	ENSGGOP00000034785	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.879
BCAR1	PTK2	ENSGGOP00000052326	ENSGGOP00000021868	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.999
BCAR1	SRC	ENSGGOP00000052326	ENSGGOP00000018321	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.999
DCC	FYN	ENSGGOP00000007195	ENSGGOP00000007888	DCC netrin 1 receptor.	Tyrosine-protein kinase.	0.602
DCC	PTK2	ENSGGOP00000007195	ENSGGOP00000021868	DCC netrin 1 receptor.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.990
DCC	SRC	ENSGGOP00000007195	ENSGGOP00000018321	DCC netrin 1 receptor.	Tyrosine-protein kinase.	0.949
EGFR	BCAR1	ENSGGOP00000041101	ENSGGOP00000052326	Receptor protein-tyrosine kinase.	BCAR1 scaffold protein, Cas family member.	0.571
EGFR	ENSGGOP00000044113	ENSGGOP00000041101	ENSGGOP00000044113	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.637
EGFR	FYN	ENSGGOP00000041101	ENSGGOP00000007888	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.750
EGFR	GRB2	ENSGGOP00000041101	ENSGGOP00000005990	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	ITGB1	ENSGGOP00000041101	ENSGGOP00000034785	Receptor protein-tyrosine kinase.	Integrin beta; Belongs to the integrin beta chain family.	0.832
EGFR	PTEN	ENSGGOP00000041101	ENSGGOP00000000877	Receptor protein-tyrosine kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.846
EGFR	PTK2	ENSGGOP00000041101	ENSGGOP00000021868	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.999
EGFR	SOS1	ENSGGOP00000041101	ENSGGOP00000022879	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
EGFR	SRC	ENSGGOP00000041101	ENSGGOP00000018321	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.998
ENSGGOP00000044113	BCAR1	ENSGGOP00000044113	ENSGGOP00000052326	Uncharacterized protein.	BCAR1 scaffold protein, Cas family member.	0.978