MSH2 protein (Gorilla gorilla) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	ENSGGOP00000038644	ENSGGOP00000023921	ENSGGOP00000038644	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL_C domain-containing protein.	0.413
BRCA1	EXO1	ENSGGOP00000023921	ENSGGOP00000013234	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Exonuclease 1.	0.872
BRCA1	G3QY63_GORGO	ENSGGOP00000023921	ENSGGOP00000007792	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA_mis_repair domain-containing protein.	0.519
BRCA1	G3R048_GORGO	ENSGGOP00000023921	ENSGGOP00000008525	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.551
BRCA1	MLH1	ENSGGOP00000023921	ENSGGOP00000015949	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL homolog 1.	0.970
BRCA1	MSH2	ENSGGOP00000023921	ENSGGOP00000006940	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.932
BRCA1	MSH6	ENSGGOP00000023921	ENSGGOP00000018924	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.904
BRCA1	PCNA	ENSGGOP00000023921	ENSGGOP00000001670	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.663
ENSGGOP00000038644	BRCA1	ENSGGOP00000038644	ENSGGOP00000023921	MutL_C domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.413
ENSGGOP00000038644	EXO1	ENSGGOP00000038644	ENSGGOP00000013234	MutL_C domain-containing protein.	Exonuclease 1.	0.906
ENSGGOP00000038644	G3QY63_GORGO	ENSGGOP00000038644	ENSGGOP00000007792	MutL_C domain-containing protein.	DNA_mis_repair domain-containing protein.	0.600
ENSGGOP00000038644	G3R048_GORGO	ENSGGOP00000038644	ENSGGOP00000008525	MutL_C domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.918
ENSGGOP00000038644	MLH1	ENSGGOP00000038644	ENSGGOP00000015949	MutL_C domain-containing protein.	MutL homolog 1.	0.984
ENSGGOP00000038644	MSH2	ENSGGOP00000038644	ENSGGOP00000006940	MutL_C domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.958
ENSGGOP00000038644	MSH6	ENSGGOP00000038644	ENSGGOP00000018924	MutL_C domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.958
ENSGGOP00000038644	PCNA	ENSGGOP00000038644	ENSGGOP00000001670	MutL_C domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.801
ENSGGOP00000038644	PMS1	ENSGGOP00000038644	ENSGGOP00000050523	MutL_C domain-containing protein.	PMS1 homolog 1, mismatch repair system component.	0.668
EXO1	BRCA1	ENSGGOP00000013234	ENSGGOP00000023921	Exonuclease 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.872
EXO1	ENSGGOP00000038644	ENSGGOP00000013234	ENSGGOP00000038644	Exonuclease 1.	MutL_C domain-containing protein.	0.906
EXO1	G3QY63_GORGO	ENSGGOP00000013234	ENSGGOP00000007792	Exonuclease 1.	DNA_mis_repair domain-containing protein.	0.906