TICAM2 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000021036	G3QUW7_GORGO	ENSGGOP00000021036	ENSGGOP00000006528	annotation not available	TIR domain-containing adapter molecule 1.	0.836
ENSGGOP00000021036	RIPK1	ENSGGOP00000021036	ENSGGOP00000012277	annotation not available	Receptor interacting serine/threonine kinase 1.	0.619
ENSGGOP00000021036	TICAM2	ENSGGOP00000021036	ENSGGOP00000023640	annotation not available	Toll like receptor adaptor molecule 2.	0.828
ENSGGOP00000021036	TLR2	ENSGGOP00000021036	ENSGGOP00000003012	annotation not available	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.749
ENSGGOP00000021036	TLR3	ENSGGOP00000021036	ENSGGOP00000027247	annotation not available	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.677
ENSGGOP00000021036	TRAF6	ENSGGOP00000021036	ENSGGOP00000005734	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.860
G3QUW7_GORGO	ENSGGOP00000021036	ENSGGOP00000006528	ENSGGOP00000021036	TIR domain-containing adapter molecule 1.	annotation not available	0.836
G3QUW7_GORGO	G3RID2_GORGO	ENSGGOP00000006528	ENSGGOP00000015431	TIR domain-containing adapter molecule 1.	TIR domain-containing protein.	0.956
G3QUW7_GORGO	RIPK1	ENSGGOP00000006528	ENSGGOP00000012277	TIR domain-containing adapter molecule 1.	Receptor interacting serine/threonine kinase 1.	0.991
G3QUW7_GORGO	TICAM2	ENSGGOP00000006528	ENSGGOP00000023640	TIR domain-containing adapter molecule 1.	Toll like receptor adaptor molecule 2.	0.972
G3QUW7_GORGO	TLR2	ENSGGOP00000006528	ENSGGOP00000003012	TIR domain-containing adapter molecule 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.966
G3QUW7_GORGO	TLR3	ENSGGOP00000006528	ENSGGOP00000027247	TIR domain-containing adapter molecule 1.	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.994
G3QUW7_GORGO	TLR4	ENSGGOP00000006528	ENSGGOP00000020706	TIR domain-containing adapter molecule 1.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.982
G3QUW7_GORGO	TMED2	ENSGGOP00000006528	ENSGGOP00000028359	TIR domain-containing adapter molecule 1.	Transmembrane p24 trafficking protein 2.	0.852
G3QUW7_GORGO	TRAF6	ENSGGOP00000006528	ENSGGOP00000005734	TIR domain-containing adapter molecule 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.996
G3R2F3_GORGO	TICAM2	ENSGGOP00000009403	ENSGGOP00000023640	Tripartite motif containing 55.	Toll like receptor adaptor molecule 2.	0.892
G3RID2_GORGO	G3QUW7_GORGO	ENSGGOP00000015431	ENSGGOP00000006528	TIR domain-containing protein.	TIR domain-containing adapter molecule 1.	0.956
G3RID2_GORGO	TICAM2	ENSGGOP00000015431	ENSGGOP00000023640	TIR domain-containing protein.	Toll like receptor adaptor molecule 2.	0.945
G3RID2_GORGO	TLR2	ENSGGOP00000015431	ENSGGOP00000003012	TIR domain-containing protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.926
G3RID2_GORGO	TLR3	ENSGGOP00000015431	ENSGGOP00000027247	TIR domain-containing protein.	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.807