STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
G3R256_GORGOSET and MYND domain containing 1. (477 aa)    
Predicted Functional Partners:
G3QX31_GORGO
Embryonic ectoderm development.
   
 0.562
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.539
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
    
 0.538
G3RHQ4_GORGO
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
   
 0.531
TP63
Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
   
 0.531
SUZ12
SUZ12 polycomb repressive complex 2 subunit.
    
 0.529
KDM6B
Lysine demethylase 6B.
   
 0.469
G3S4D8_GORGO
Lysine demethylase 6A.
   
 0.469
MPHOSPH8
M-phase phosphoprotein 8.
    
 0.466
SETD1B
SET domain containing 1B, histone lysine methyltransferase.
    
 0.446
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.