STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSGGOP00000032367IRS-type PTB domain-containing protein. (444 aa)    
Predicted Functional Partners:
RET
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
    
  0.813
RASA1
RAS p21 protein activator 1.
    
 
 0.692
ABL1
Tyrosine-protein kinase.
    
 0.555
G3R6S0_GORGO
Tyrosine-protein kinase.
    
 0.555
CSK
Tyrosine-protein kinase.
    
 0.544
CRKL
Uncharacterized protein.
    
 0.541
ENSGGOP00000048050
SH2 domain-containing protein.
    
 0.541
CRK
CRK proto-oncogene, adaptor protein.
    
 0.492
G3QTT4_GORGO
Neurturin.
     
 0.487
G3RFH4_GORGO
Tyrosine-protein kinase.
    
 0.460
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.