| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALAS2 | SNCA | ENSGGOP00000002027 | ENSGGOP00000027281 | 5-aminolevulinate synthase. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.995 |
| APP | HSPA4 | ENSGGOP00000049928 | ENSGGOP00000029381 | Amyloid beta precursor protein. | Heat shock protein family A (Hsp70) member 4. | 0.488 |
| APP | PRKN | ENSGGOP00000049928 | ENSGGOP00000038323 | Amyloid beta precursor protein. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.680 |
| APP | SNCA | ENSGGOP00000049928 | ENSGGOP00000027281 | Amyloid beta precursor protein. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.948 |
| G3QN04_GORGO | PRKN | ENSGGOP00000003905 | ENSGGOP00000038323 | Tyrosine hydroxylase. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.492 |
| G3QN04_GORGO | SLC18A2 | ENSGGOP00000003905 | ENSGGOP00000049130 | Tyrosine hydroxylase. | Solute carrier family 18 member A2. | 0.662 |
| G3QN04_GORGO | SLC6A3 | ENSGGOP00000003905 | ENSGGOP00000021465 | Tyrosine hydroxylase. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.744 |
| G3QN04_GORGO | SNCA | ENSGGOP00000003905 | ENSGGOP00000027281 | Tyrosine hydroxylase. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.971 |
| HSPA4 | APP | ENSGGOP00000029381 | ENSGGOP00000049928 | Heat shock protein family A (Hsp70) member 4. | Amyloid beta precursor protein. | 0.488 |
| HSPA4 | PRKN | ENSGGOP00000029381 | ENSGGOP00000038323 | Heat shock protein family A (Hsp70) member 4. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.945 |
| HSPA4 | SNCA | ENSGGOP00000029381 | ENSGGOP00000027281 | Heat shock protein family A (Hsp70) member 4. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.956 |
| KIF5B | SNCA | ENSGGOP00000013097 | ENSGGOP00000027281 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.941 |
| PRKN | APP | ENSGGOP00000038323 | ENSGGOP00000049928 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Amyloid beta precursor protein. | 0.680 |
| PRKN | G3QN04_GORGO | ENSGGOP00000038323 | ENSGGOP00000003905 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Tyrosine hydroxylase. | 0.492 |
| PRKN | HSPA4 | ENSGGOP00000038323 | ENSGGOP00000029381 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Heat shock protein family A (Hsp70) member 4. | 0.945 |
| PRKN | SLC6A3 | ENSGGOP00000038323 | ENSGGOP00000021465 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.555 |
| PRKN | SNCA | ENSGGOP00000038323 | ENSGGOP00000027281 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.997 |
| PRKN | SNCAIP | ENSGGOP00000038323 | ENSGGOP00000015067 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Synuclein alpha interacting protein. | 0.999 |
| SLC18A2 | G3QN04_GORGO | ENSGGOP00000049130 | ENSGGOP00000003905 | Solute carrier family 18 member A2. | Tyrosine hydroxylase. | 0.662 |
| SLC18A2 | SLC6A3 | ENSGGOP00000049130 | ENSGGOP00000021465 | Solute carrier family 18 member A2. | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.717 |
