STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFBComplement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity). (1112 aa)    
Predicted Functional Partners:
C3
Complement C3.
   
 0.996
CFH
Complement factor H.
   
 0.976
CFP
Complement factor properdin.
   
 0.920
ENSGGOP00000042007
Complement factor D; Belongs to the peptidase S1 family.
    
 0.893
G3RPZ9_GORGO
Anaphylatoxin-like domain-containing protein.
   
 0.810
ENSGGOP00000044488
Uncharacterized protein.
   
 0.810
CFI
Complement factor I; Belongs to the peptidase S1 family.
   
 
 0.767
C5
Complement C5.
   
 0.754
SERPING1
Serpin family G member 1; Belongs to the serpin family.
   
 0.723
CD55
Uncharacterized protein.
    
0.688
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.