STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)    
Predicted Functional Partners:
ENSGGOP00000044113
Uncharacterized protein.
   
 0.995
G3R9C2_GORGO
Proline-serine-threonine phosphatase interacting protein 1.
   
 
 0.929
EGFR
Receptor protein-tyrosine kinase.
    
 0.901
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 
 0.891
CSK
Tyrosine-protein kinase.
   
 0.886
SHC1
SHC adaptor protein 1.
   
 0.871
G3RSU6_GORGO
Uncharacterized protein.
   
 0.871
LPXN
Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN).
   
 0.859
PSTPIP2
Proline-serine-threonine phosphatase interacting protein 2.
   
 
 0.855
ERBB2
Receptor protein-tyrosine kinase.
    
 0.798
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.