CUL5 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOBEC3G	CUL5	ENSGGOP00000021965	ENSGGOP00000027637	DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...]	Cullin 5; Belongs to the cullin family.	0.978
APOBEC3G	ELOB	ENSGGOP00000021965	ENSGGOP00000014931	DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...]	Elongin B.	0.965
APOBEC3G	ELOC	ENSGGOP00000021965	ENSGGOP00000002153	DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...]	Elongin C; Belongs to the SKP1 family.	0.955
APOBEC3G	G3R2E6_GORGO	ENSGGOP00000021965	ENSGGOP00000009396	DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...]	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.944
APOBEC3G	G3RD21_GORGO	ENSGGOP00000021965	ENSGGOP00000013413	DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...]	Apolipoprotein B mRNA editing enzyme catalytic subunit 3F.	0.950
APOBEC3G	RNF7	ENSGGOP00000021965	ENSGGOP00000001803	DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the p [...]	Ring finger protein 7.	0.937
CAND1	COPS5	ENSGGOP00000000863	ENSGGOP00000026909	Cullin associated and neddylation dissociated 1.	COP9 signalosome subunit 5.	0.512
CAND1	CUL5	ENSGGOP00000000863	ENSGGOP00000027637	Cullin associated and neddylation dissociated 1.	Cullin 5; Belongs to the cullin family.	0.980
CAND1	ELOB	ENSGGOP00000000863	ENSGGOP00000014931	Cullin associated and neddylation dissociated 1.	Elongin B.	0.507
CAND1	ELOC	ENSGGOP00000000863	ENSGGOP00000002153	Cullin associated and neddylation dissociated 1.	Elongin C; Belongs to the SKP1 family.	0.491
CAND1	G3QLU7_GORGO	ENSGGOP00000000863	ENSGGOP00000003465	Cullin associated and neddylation dissociated 1.	RING-type domain-containing protein.	0.983
CAND1	G3R2E6_GORGO	ENSGGOP00000000863	ENSGGOP00000009396	Cullin associated and neddylation dissociated 1.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.491
CAND1	RNF7	ENSGGOP00000000863	ENSGGOP00000001803	Cullin associated and neddylation dissociated 1.	Ring finger protein 7.	0.791
CAND1	SOCS2	ENSGGOP00000000863	ENSGGOP00000009942	Cullin associated and neddylation dissociated 1.	Suppressor of cytokine signaling 2.	0.574
COPS5	CAND1	ENSGGOP00000026909	ENSGGOP00000000863	COP9 signalosome subunit 5.	Cullin associated and neddylation dissociated 1.	0.512
COPS5	CUL5	ENSGGOP00000026909	ENSGGOP00000027637	COP9 signalosome subunit 5.	Cullin 5; Belongs to the cullin family.	0.976
COPS5	ELOB	ENSGGOP00000026909	ENSGGOP00000014931	COP9 signalosome subunit 5.	Elongin B.	0.706
COPS5	ELOC	ENSGGOP00000026909	ENSGGOP00000002153	COP9 signalosome subunit 5.	Elongin C; Belongs to the SKP1 family.	0.761
COPS5	G3QLU7_GORGO	ENSGGOP00000026909	ENSGGOP00000003465	COP9 signalosome subunit 5.	RING-type domain-containing protein.	0.938
COPS5	G3R2E6_GORGO	ENSGGOP00000026909	ENSGGOP00000009396	COP9 signalosome subunit 5.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.754