TMED3 protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSGGOP00000045150	SURF4	ENSGGOP00000045150	ENSGGOP00000026006	GOLD domain-containing protein.	Surfeit 4.	0.842
ENSGGOP00000045150	TMED2	ENSGGOP00000045150	ENSGGOP00000028359	GOLD domain-containing protein.	Transmembrane p24 trafficking protein 2.	0.994
ENSGGOP00000045150	TMED3	ENSGGOP00000045150	ENSGGOP00000034702	GOLD domain-containing protein.	GOLD domain-containing protein.	0.907
ENSGGOP00000045150	TMED4	ENSGGOP00000045150	ENSGGOP00000011752	GOLD domain-containing protein.	Transmembrane p24 trafficking protein 4.	0.940
ENSGGOP00000045150	TMED9	ENSGGOP00000045150	ENSGGOP00000004999	GOLD domain-containing protein.	Transmembrane p24 trafficking protein 9.	0.950
MAP3K7	TLR3	ENSGGOP00000020634	ENSGGOP00000027247	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	0.880
MAP3K7	TLR4	ENSGGOP00000020634	ENSGGOP00000020706	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.855
MAP3K7	TMED3	ENSGGOP00000020634	ENSGGOP00000034702	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	GOLD domain-containing protein.	0.728
MAP3K7	TRAF3	ENSGGOP00000020634	ENSGGOP00000004192	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.957
SURF4	ENSGGOP00000045150	ENSGGOP00000026006	ENSGGOP00000045150	Surfeit 4.	GOLD domain-containing protein.	0.842
SURF4	TMED10	ENSGGOP00000026006	ENSGGOP00000018339	Surfeit 4.	Transmembrane p24 trafficking protein 10.	0.842
SURF4	TMED2	ENSGGOP00000026006	ENSGGOP00000028359	Surfeit 4.	Transmembrane p24 trafficking protein 2.	0.922
SURF4	TMED3	ENSGGOP00000026006	ENSGGOP00000034702	Surfeit 4.	GOLD domain-containing protein.	0.792
SURF4	TMED4	ENSGGOP00000026006	ENSGGOP00000011752	Surfeit 4.	Transmembrane p24 trafficking protein 4.	0.860
SURF4	TMED9	ENSGGOP00000026006	ENSGGOP00000004999	Surfeit 4.	Transmembrane p24 trafficking protein 9.	0.850
TLR3	MAP3K7	ENSGGOP00000027247	ENSGGOP00000020634	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.880
TLR3	TLR4	ENSGGOP00000027247	ENSGGOP00000020706	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.735
TLR3	TMED3	ENSGGOP00000027247	ENSGGOP00000034702	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	GOLD domain-containing protein.	0.747
TLR3	TRAF3	ENSGGOP00000027247	ENSGGOP00000004192	Toll-like receptor 3 precursor; Belongs to the Toll-like receptor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.965
TLR4	MAP3K7	ENSGGOP00000020706	ENSGGOP00000020634	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.855